Genome-Wide Expression Profile Analysis of 3D Cultured Dermal Papilla Cells from Patients with Androgenic Alopecia

    March 2014 in “ Chinese Journal of Dermatology ”
    Weiling Sun, You-You Zheng, Jiajia Xu, Li-Fang Hu, Weixin Fan
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    TLDR Hair loss in androgenic alopecia patients is linked to changes in certain genes that control cell growth and death.
    In 2014, a study was conducted to investigate the differences in gene expression profiles of 3D cultured dermal papilla cells from patients with androgenic alopecia. The study involved treating the cells with dihydrotestosterone, extracting total RNA for amplification, and using Cy3 labeling for hybridization with a NimbleGen human genome-wide expression array. The results showed that out of 622 differentially expressed genes, 359 were upregulated and 263 were downregulated. Genes inhibiting cell proliferation and promoting apoptosis, such as CHEK1 and Tob1, were upregulated. Genes promoting cell proliferation and involved in epidermal growth and development, such as BAMBI, EFNA3, Dlx3, and UCGC, were downregulated. The study concluded that the pathogenesis of androgenic alopecia is regulated by various signaling molecules and pathways, possibly focusing on the regulation of the cell cycle, cell proliferation, and apoptosis.
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