Gene Expression Profile of Human Follicle Dermal Papilla Cells in Response to Camellia Japonica Phytoplacenta Extract

February 2021 in “ FEBS open bio ”

Won Kyong Cho, Hyein Kim, Seung Hye Paek, Sooyun Kim, Hyo Hyun Seo, Jihyeok Song, Ok Hwa Lee, Jiae Min, Sang Jun Lee, Yeonhwa Jo, Hoseong Choi, Jeong Hun Lee, Sang Hyun Moh

Camellia japonica placenta extract CJPE hair growth marker genes human follicle dermal papilla cells HFDPC scalp moisture scalp sebum dead scalp keratin erythema lipid metabolism cholesterol efflux parathyroid hormone α-melanocyte-stimulating hormone hair follicle function axon guidance cytoskeleton muscle structure

TLDR Camellia japonica extract may improve scalp health and promote hair growth.

The study investigated the effects of Camellia japonica phytoplacenta extract (CJPE) on human follicle dermal papilla cells (HFDPC) and scalp health. CJPE significantly upregulated genes related to hair growth and follicle development, particularly those in the Wnt signaling pathway. In vitro assays showed increased expression of hair growth markers, and in vivo clinical tests with 42 adult females demonstrated improved scalp moisture, reduced sebum, decreased dead scalp keratin, and lessened erythema. RNA-seq analysis identified 254 differentially expressed genes, suggesting CJPE as a promising therapeutic agent for promoting hair growth and treating alopecia.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Cited in this study

14 / 14 results

research Cholesterol Homeostasis: Links to Hair Follicle Biology and Hair Disorders

25 citations , August 2019 in “Experimental Dermatology”

Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.

research Minoxidil And Its Use In Hair Disorders: A Review

117 citations , August 2019 in “Drug Design Development and Therapy”

Minoxidil effectively treats hair loss, but use cautiously and monitor side effects.

research Stimulation of Hair Growth by Small Molecules That Activate Autophagy

88 citations , June 2019 in “Cell reports”

Certain small molecules can promote hair growth by activating a cellular cleanup process called autophagy.

research Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms

52 citations , September 2018 in “International Journal of Molecular Sciences”

Ginseng and its compounds may help hair growth and prevent hair loss, but more human trials are needed to confirm this.

research Scalp Condition Impacts Hair Growth And Retention Via Oxidative Stress

40 citations , January 2018 in “International journal of trichology”

Healthy scalp reduces hair loss by managing oxidative stress.

research Norepinephrine Regulates Keratinocyte Proliferation to Promote the Growth of Hair Follicles

8 citations , January 2016 in “Cells tissues organs”

Norepinephrine helps skin cells grow, which is important for hair growth.

research The Effect of Parathyroid Hormones on Hair Follicle Physiology: Implications for Treatment of Chemotherapy-Induced Alopecia

15 citations , January 2015 in “Skin Pharmacology and Physiology”

Parathyroid hormones are important for hair growth, but their use in treating hair loss from chemotherapy is still uncertain.

research Hair Growth Defects in Insig-Deficient Mice Caused by Cholesterol Precursor Accumulation and Reversed by Simvastatin

46 citations , May 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mice lacking Insig proteins had hair growth problems due to cholesterol buildup, but this was fixed by the drug simvastatin.

research Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

314 citations , April 2010 in “Developmental Cell”

β-catenin in the dermal papilla is crucial for normal hair growth and repair.

research Review of Hair Follicle Dermal Cells

321 citations , January 2010 in “Journal of Dermatological Science”

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.

research The Chemokine SDF-1/CXCL12 Regulates the Migration of Melanocyte Progenitors in Mouse Hair Follicles

57 citations , April 2009 in “Differentiation”

SDF-1/CXCL12 and its receptor CXCR4 are crucial for melanocyte movement in mouse hair follicles.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations , February 2009 in “Current Biology”

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

research Molecular Mechanisms Regulating Hair Follicle Development

854 citations , February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

520 citations , February 2001 in “Journal of Clinical Investigation”

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.