Gene Expression Profile of Human Follicle Dermal Papilla Cells in Response to Camellia Japonica Phytoplacenta Extract

January 2021 in “ FEBS open bio ”

Won Kyong Cho, Hyein Kim, Seung Hye Paek, Sooyun Kim, Hyo Hyun Seo, Jihyeok Song, Ok Hwa Lee, Jiae Min, Sang Jun Lee, Yeonhwa Jo, Hoseong Choi, Jeong Hun Lee, Sang Hyun Moh

Camellia japonica placenta extract CJPE hair growth marker genes human follicle dermal papilla cells HFDPC scalp moisture scalp sebum dead scalp keratin erythema lipid metabolism cholesterol efflux parathyroid hormone α-melanocyte-stimulating hormone hair follicle function axon guidance cytoskeleton muscle structure

Studysummary This study found that a solution containing 0.5% Camellia japonica placenta extract increased scalp moisture and reduced sebum content, dead keratin, and erythema in adult females, suggesting potential as a scalp treatment. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigated the effects of Camellia japonica phytoplacenta extract (CJPE) on human follicle dermal papilla cells (HFDPC) and scalp health. CJPE significantly upregulated genes related to hair growth and follicle development, particularly those in the Wnt signaling pathway. In vitro assays showed increased expression of hair growth markers, and in vivo clinical tests with 42 adult females demonstrated improved scalp moisture, reduced sebum, decreased dead scalp keratin, and lessened erythema. RNA-seq analysis identified 254 differentially expressed genes, suggesting CJPE as a promising therapeutic agent for promoting hair growth and treating alopecia.

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