Gene Expression Profile of Human Follicle Dermal Papilla Cells in Response to Camellia Japonica Phytoplacenta Extract

    February 2021 in “ FEBS open bio
    Won Kyong Cho, Hyein Kim, Seung Hye Paek, Sooyun Kim, Hyo Hyun Seo, Jihyeok Song, Ok Hwa Lee, Jiae Min, Sang Jun Lee, Yeonhwa Jo, Hoseong Choi, Jeong Hun Lee, Sang Hyun Moh
    TLDR Camellia japonica extract may improve scalp health and promote hair growth.
    The study investigated the effects of Camellia japonica phytoplacenta extract (CJPE) on human follicle dermal papilla cells (HFDPC) and scalp health. CJPE significantly upregulated genes related to hair growth and follicle development, particularly those in the Wnt signaling pathway. In vitro assays showed increased expression of hair growth markers, and in vivo clinical tests with 42 adult females demonstrated improved scalp moisture, reduced sebum, decreased dead scalp keratin, and lessened erythema. RNA-seq analysis identified 254 differentially expressed genes, suggesting CJPE as a promising therapeutic agent for promoting hair growth and treating alopecia.
    Discuss this study in the Community →

    Research cited in this study

    16 / 16 results

    Related Community Posts Join

    4 / 4 results

      community Why is no one talking about redensyl?

      in Question  57 upvotes 4 years ago
      Exploring the effectiveness of redensyl, a hair loss treatment, compared to minoxidil and finasteride. People shared experiences using redensyl and products containing it, such as The Ordinary Hair Serum.

      community Any young women losing hair that have tried microneedling and oils?

      in Microneedling  32 upvotes 4 years ago
      A 25-year-old woman is experiencing hair loss and has started microneedling with a 0.5mm roller, applying a mix of essential oils overnight. She questions whether to switch to a 1.5mm roller and the best order for her routine, while a reply suggests using Minoxidil for better results.

      community This serum outperformed Minoxidil in a recent study. Please debunk

       23 upvotes 5 years ago
      A topical solution called "Multi-Peptide Serum for Hair Density" by The Ordinary Company, which contains several ingredients that are used in alternatives to Minoxidil and was found to have better results than 5% Minoxidil in a study. People who have tried it shared their experiences with the serum as well.

    Similar Research

    5 / 199 results