Gene Expression Profile of Human Follicle Dermal Papilla Cells in Response to Camellia Japonica Phytoplacenta Extract

    February 2021 in “ FEBS open bio
    Won Kyong Cho, Hyein Kim, Seung Hye Paek, Sooyun Kim, Hyo Hyun Seo, Jihyeok Song, Ok Hwa Lee, Jiae Min, Sang Jun Lee, Yeonhwa Jo, Hoseong Choi, Jeong Hun Lee, Sang Hyun Moh
    TLDR Camellia japonica extract may improve scalp health and promote hair growth.
    The study investigated the effects of Camellia japonica phytoplacenta extract (CJPE) on human follicle dermal papilla cells (HFDPC) and scalp health. CJPE significantly upregulated genes related to hair growth and follicle development, particularly those in the Wnt signaling pathway. In vitro assays showed increased expression of hair growth markers, and in vivo clinical tests with 42 adult females demonstrated improved scalp moisture, reduced sebum, decreased dead scalp keratin, and lessened erythema. RNA-seq analysis identified 254 differentially expressed genes, suggesting CJPE as a promising therapeutic agent for promoting hair growth and treating alopecia.
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