Norepinephrine Regulates Keratinocyte Proliferation to Promote the Growth of Hair Follicles

January 2016 in “ Cells tissues organs ”

Yanan Kong, Yishu Liu, Liangli Pan, Biao Cheng, Hongwei Liu

norepinephrine keratinocyte proliferation hair follicle growth chemical sympathectomy 6-hydroxydopamine β-adrenoceptor antagonist propranolol α-adrenergic receptors adrenergic signaling pathways alopecia NE 6-OHDA PR

Studysummary This study found that chemical sympathectomy inhibited hair follicle growth in mice, suggesting that sympathetic nerves may regulate keratinocyte behavior to promote hair growth. Our plain-language summary of this paper — not a Tressless recommendation.

The study demonstrated that norepinephrine (NE) from the sympathetic nervous system played a crucial role in promoting hair follicle (HF) growth by regulating keratinocyte proliferation. Using 90 female C57BL/6 mice, the researchers found that chemical sympathectomy with 6-hydroxydopamine (6-OHDA) inhibited HF growth, while treatment with the β-adrenoceptor antagonist propranolol (PR) did not affect HF growth. NE promoted HF initiation in cultured neonatal skin, suggesting its pivotal role in hair growth through α-adrenergic receptors. The findings suggested that targeting adrenergic signaling pathways could offer new strategies for managing hair growth and alopecia.

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