Norepinephrine Regulates Keratinocyte Proliferation to Promote the Growth of Hair Follicles

The study demonstrated that norepinephrine (NE) from the sympathetic nervous system played a crucial role in promoting hair follicle (HF) growth by regulating keratinocyte proliferation. Using 90 female C57BL/6 mice, the researchers found that chemical sympathectomy with 6-hydroxydopamine (6-OHDA) inhibited HF growth, while treatment with the β-adrenoceptor antagonist propranolol (PR) did not affect HF growth. NE promoted HF initiation in cultured neonatal skin, suggesting its pivotal role in hair growth through α-adrenergic receptors. The findings suggested that targeting adrenergic signaling pathways could offer new strategies for managing hair growth and alopecia.