Activin B Promotes Epithelial Wound Healing In Vivo Through RhoA-JNK Signaling Pathway

    September 2011 in “ PLOS ONE ”
    Min Zhang, Nuyun Liu, Xueer Wang … Lu Zhang
    Studysummary This study found that activin B promotes epithelial wound healing in mice through the RhoA-Rock-JNK-cJun signaling pathway, suggesting a potential therapeutic role for activin B in wound repair.
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    Research cited in this study 9

    1. The Role of Activins and Follistatins in Skin and Hair Follicle Development and Function Cytokine & Growth Factor Reviews · 2008
    2. An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell Contribution ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2007
    3. New Hair From Healing Wounds Nature · 2007
    4. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    5. Activin Controls Skin Morphogenesis and Wound Repair Predominantly via Stromal Cells and in a Concentration-Dependent Manner via Keratinocytes ˜The œAmerican journal of pathology · 2005
    6. Impaired Wound Healing in Transgenic Mice Overexpressing the Activin Antagonist Follistatin in the Epidermis EMBO journal · 2001
    7. The Roles of Activins in Repair Processes of the Skin and the Brain Molecular and cellular endocrinology · 2001
    8. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000
    9. The Biology of Hair Follicles The New England Journal of Medicine · 1999