Alteration of Skin Wound Healing in Keratinocyte-Specific Mediator Complex Subunit 1 Null Mice

    August 2014 in “ PloS one
    Fumihito Noguchi, Takeshi Nakajima, Shigeki Inui, Janardan K. Reddy, Satoshi Itami
    Image of study
    TLDR MED1 affects skin wound healing differently in young and old mice.
    The study investigated the role of MED1 in skin wound healing using keratinocyte-specific MED1 null mice (Med1(epi-/-)). In 8-week-old Med1(epi-/-) mice, wound healing was accelerated with increased epithelial migration and cell proliferation, linked to decreased follistatin expression and enhanced MAPK pathway activity. However, in 6-month-old Med1(epi-/-) mice, wound healing was delayed with reduced cell proliferation and hair follicle stem cell contribution, aligning with previous findings of diminished hair follicle bulge stem cells in older mice. This highlighted MED1's novel function in keratinocytes and suggested potential therapeutic approaches for skin wound healing and aging.
    Discuss this study in the Community →

    Research cited in this study

    12 / 12 results

    Related Community Posts Join

    6 / 26 results

      community Sandalore: a scientific homemade approch

       20 upvotes 6 years ago
      The post discusses using Sandalore as a potential hair loss treatment, emphasizing precise measurements and safe handling. The user compares Sandalore's effects to Minoxidil and mentions preparing a solution with ethanol and DMSO.

      community Painkillers May Block Minoxidil

      in Research/Science  15 upvotes 2 weeks ago
      Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.

      community DLQ01: A Better "Minoxidil" PGF2a synthetic analogue.

      in Research/Science  3 upvotes 1 month ago
      DLQ01, a prostaglandin F2α analog, shows promise for hair growth by directly stimulating PGE2/PGF receptors without needing conversion, and can be combined with minoxidil and retinoids like tretinoin for enhanced effectiveness. Minoxidil's efficacy may be reduced by COX-1 inhibitors, but using prostaglandin analogs like Latanoprost or Bimatoprost can help maintain its effectiveness.

      community Opinions on this study for Triphasic Progressive by Rene Furterer

      in Research/Science  14 upvotes 1 year ago
      The user shared their 5-year hair loss journey, initially using a product called Triphasic Progressive by Rene Furterer, which gave good results. Later, they switched to FDA-approved medications finasteride and minoxidil, which also helped, but they noticed the most significant progress with Triphasic. They're considering trying it again if minoxidil doesn't show improvements.

      community SAFFLOWER OIL good alternative for Minoxidil?

      in Treatment  1 upvotes 5 years ago
      Safflower oil is suggested as an alternative to minoxidil for hair growth, with benefits including scalp conditioning and hair strength enhancement. Studies indicate it may also reverse scalp dermatitis, alopecia, and prevent premature grayness.

    Similar Research

    5 / 1000+ results