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    Alteration of Skin Wound Healing in Keratinocyte-Specific Mediator Complex Subunit 1 Null Mice

    August 2014 in “ PloS one ”
    Fumihito Noguchi, Takeshi Nakajima, Shigeki Inui … Satoshi Itami
    Studysummary This study found that MED1 deficiency in keratinocytes accelerates skin wound healing in young mice but delays healing in older mice, suggesting differential roles in epidermal regeneration with age.
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    Research cited in this study 19

    1. Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alterations ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2011
    2. Activin B Promotes Epithelial Wound Healing In Vivo Through RhoA-JNK Signaling Pathway PLOS ONE · 2011
    3. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011
    4. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    5. Exploring the Role of Stem Cells in Cutaneous Wound Healing Experimental Dermatology · 2009
    6. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    7. Keratinocyte-Derived Follistatin Regulates Epidermal Homeostasis and Wound Repair Laboratory investigation · 2008
    8. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    9. The Role of Activins and Follistatins in Skin and Hair Follicle Development and Function Cytokine & Growth Factor Reviews · 2008
    10. More Than One Way to Skin Genes & Development · 2008
    11. Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells Cell · 2008
    12. Epidermal Stem Cells Are Defined by Global Histone Modifications Altered by Myc-Induced Differentiation PLoS ONE · 2007
    13. Vitamin D Receptor Is Essential For Normal Keratinocyte Stem Cell Function Proceedings of the National Academy of Sciences · 2007
    14. Development and Progression of Alopecia in the Vitamin D Receptor Null Mouse Journal of cellular physiology · 2006
    15. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    16. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    17. Impaired Wound Healing in Transgenic Mice Overexpressing the Activin Antagonist Follistatin in the Epidermis EMBO journal · 2001
    18. The Roles of Activins in Repair Processes of the Skin and the Brain Molecular and cellular endocrinology · 2001
    19. Overexpression of Activin A in the Skin of Transgenic Mice Reveals New Activities in Epidermal Morphogenesis, Dermal Fibrosis, and Wound Repair EMBO journal · 1999