Keratinocyte-Derived Follistatin Regulates Epidermal Homeostasis and Wound Repair

    December 2008 in “ Laboratory investigation ”
    Maria Antsiferova, Jennifer E. Klatte, Enikõ Bodó, Ralf Paus, José L. Jorcano, Martin M. Matzuk, Sabine Werner, Heidi Kögel
    Image of study
    TLDR Activin activation in skin cells speeds up wound healing without affecting scar quality.
    In this study, researchers generated mice lacking the activin antagonist follistatin in keratinocytes to explore the effects of targeted activin activation in the epidermis and hair follicles. They observed enhanced keratinocyte proliferation in the tail epidermis and an earlier onset of keratinocyte hyperproliferation at the wound edge in these mutant mice, leading to an enlarged hyperproliferative epithelium after skin injury. Despite these changes, granulation tissue formation and scarring were not affected, indicating that selective activation of activin in the epidermis enhances reepithelialization without compromising the quality of the healed wound.
    Discuss this study in the Community →

    Research cited in this study

    5 / 5 results

    Related Community Posts Join

    6 / 29 results

      community Sandalore: a scientific homemade approch

       20 upvotes 6 years ago
      The post discusses using Sandalore as a potential hair loss treatment, emphasizing precise measurements and safe handling. The user compares Sandalore's effects to Minoxidil and mentions preparing a solution with ethanol and DMSO.

      community Hair Loss Inflammation Prevention Stack

      in Research/Science  44 upvotes 1 month ago
      The conversation discusses a hair loss and scalp care routine involving ciclopirox shampoo, benzoyl peroxide, clindamycin gel, clobetasol propionate, and calcipotriol to manage seborrheic dermatitis, folliculitis, and inflammation. It also touches on the role of diet and other treatments like oral minoxidil and pioglitazone for scalp health.

      community Painkillers May Block Minoxidil

      in Research/Science  14 upvotes 2 months ago
      Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.

      community DLQ01: A Better "Minoxidil" PGF2a synthetic analogue.

      in Research/Science  3 upvotes 3 months ago
      DLQ01, a prostaglandin F2α analog, shows promise for hair growth by directly stimulating PGE2/PGF receptors without needing conversion, and can be combined with minoxidil and retinoids like tretinoin for enhanced effectiveness. Minoxidil's efficacy may be reduced by COX-1 inhibitors, but using prostaglandin analogs like Latanoprost or Bimatoprost can help maintain its effectiveness.

    Related Research

    1 / 1 results