Keratinocyte-Derived Follistatin Regulates Epidermal Homeostasis and Wound Repair

December 2008 in “ Laboratory investigation ”

Maria Antsiferova, Jennifer E. Klatte, Enikõ Bodó, Ralf Paus, José L. Jorcano, Martin M. Matzuk, Sabine Werner, Heidi Kögel

keratinocyte follistatin activin epidermis hair follicles keratinocyte proliferation hyperproliferation reepithelialization granulation tissue scarring

TLDR Activin activation in skin cells speeds up wound healing without affecting scar quality.

In this study, researchers generated mice lacking the activin antagonist follistatin in keratinocytes to explore the effects of targeted activin activation in the epidermis and hair follicles. They observed enhanced keratinocyte proliferation in the tail epidermis and an earlier onset of keratinocyte hyperproliferation at the wound edge in these mutant mice, leading to an enlarged hyperproliferative epithelium after skin injury. Despite these changes, granulation tissue formation and scarring were not affected, indicating that selective activation of activin in the epidermis enhances reepithelialization without compromising the quality of the healed wound.

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Research cited in this study

5 / 5 results

Activin Controls Skin Morphogenesis and Wound Repair Predominantly via Stromal Cells and in a Concentration-Dependent Manner via Keratinocytes

research Activin Controls Skin Morphogenesis and Wound Repair Predominantly via Stromal Cells and in a Concentration-Dependent Manner via Keratinocytes

81 citations , September 2005 in “The American journal of pathology”

Activin helps skin growth and healing mainly through stromal cells and affects keratinocytes based on its amount.

research Control of Pelage Hair Follicle Development and Cycling by Complex Interactions Between Follistatin and Activin

81 citations , January 2003 in “The FASEB Journal”

Follistatin helps hair growth and cycling, while activin prevents it.

The Activin Binding Proteins Follistatin and Follistatin-Related Protein Are Differentially Regulated In Vitro and During Cutaneous Wound Repair

research The Activin Binding Proteins Follistatin and Follistatin-Related Protein Are Differentially Regulated In Vitro and During Cutaneous Wound Repair

46 citations , December 2001 in “Journal of Endocrinology/Journal of endocrinology”

FLRG and follistatin have different roles in wound healing.

research Impaired Wound Healing in Transgenic Mice Overexpressing the Activin Antagonist Follistatin in the Epidermis

163 citations , October 2001 in “EMBO journal”

Overexpressing follistatin in mice delays wound healing and reduces scar size.

Overexpression of Activin A in the Skin of Transgenic Mice Reveals New Activities in Epidermal Morphogenesis, Dermal Fibrosis, and Wound Repair

research Overexpression of Activin A in the Skin of Transgenic Mice Reveals New Activities in Epidermal Morphogenesis, Dermal Fibrosis, and Wound Repair

204 citations , October 1999 in “EMBO journal”

Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.

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