Hair growth control by follistatin
January 2004
in “Enshou saisei”
TLDR Follistatin is important for hair growth and could help treat hair loss.
The 2004 study investigated the role of follistatin in hair follicle development and its potential in treating alopecia. It was found that follistatin mRNA is present in various parts of the hair follicle and skin, while activin BA-mRNA is primarily in dermal papilla cells. Experiments showed that both follistatin knockout and activin BA transgenic mice had delayed hair follicle development compared to normal mice. Furthermore, applying follistatin protein to embryonic skin explants promoted hair follicle growth, which was hindered by activin A protein. These findings indicate that follistatin and activin interaction is crucial for hair follicle development and may lead to new alopecia treatments. The number of mice used in the study was not mentioned.
View this study on jstage.jst.go.jp →
Cited in this study
research Control of pelage hair follicle development and cycling by complex interactions between follistatin and activin
Follistatin helps hair growth and cycling, while activin prevents it.
research Molecular Mechanisms Regulating Hair Follicle Development
Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.
research Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: annotated tables
Mutant mice help researchers understand hair growth and related genetic factors.
research Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair
Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.
Related
research Signaling Involved in Hair Follicle Morphogenesis and Development
The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.
research Mesenchymal–epithelial interactions during hair follicle morphogenesis and cycling
The conclusion is that certain cell interactions and signals are crucial for hair growth and regeneration.
research Shh maintains dermal papilla identity and hair morphogenesis via a Noggin–Shh regulatory loop
Sonic hedgehog signaling is crucial for hair growth and maintaining hair follicle identity.
research Dermal papilla cells induce keratinocyte tubulogenesis in culture
Skin cells can help create early hair-like structures in lab cultures.
research Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis
Laminin-511 is crucial for early hair growth and maintaining important hair development signals.
research Hair growth control by follistatin
Follistatin is important for hair growth and could help treat hair loss.