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GlossaryFollistatin

protein that inhibits activins, influencing muscle growth and hair

Follistatin, also known as FS or FST, is a protein that plays a crucial role in regulating various biological processes by binding to and inhibiting members of the TGF-beta superfamily, particularly activins. This inhibition is important for controlling muscle growth, inflammation, and tissue repair. In the context of hair biology, follistatin has been studied for its potential to promote hair growth and counteract conditions like alopecia by modulating the activity of growth factors involved in hair follicle development.

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learn Follistatin

glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin

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research Impaired Wound Healing in Transgenic Mice Overexpressing the Activin Antagonist Follistatin in the Epidermis

163 citations, October 2001 in “EMBO journal”

Overexpressing follistatin in mice delays wound healing and reduces scar size.

research Control of Pelage Hair Follicle Development and Cycling by Complex Interactions Between Follistatin and Activin

81 citations, January 2003 in “The FASEB Journal”

Follistatin helps hair growth and cycling, while activin prevents it.

research Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4

75 citations, March 2014 in “Journal of Investigative Dermatology”

Aging mice have slower hair regeneration due to changes in signal balance, but the environment, not stem cell loss, controls this, suggesting treatments could focus on environmental factors.

The Activin Binding Proteins Follistatin and Follistatin-Related Protein Are Differentially Regulated In Vitro and During Cutaneous Wound Repair

research The Activin Binding Proteins Follistatin and Follistatin-Related Protein Are Differentially Regulated In Vitro and During Cutaneous Wound Repair

46 citations, December 2001 in “Journal of Endocrinology/Journal of endocrinology”

FLRG and follistatin have different roles in wound healing.

research The Role of Activins and Follistatins in Skin and Hair Follicle Development and Function

45 citations, October 2008 in “Cytokine & Growth Factor Reviews”

Activins and follistatins, part of the TGFβ family, are crucial for hair follicle development and skin health, affecting growth, repair, and the hair cycle.

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community Follistatin, thoughts about a potential treatment ?

in Research/Science 7 upvotes 1 year ago

Follistatin, known for inhibiting myostatin and promoting muscle growth in mice, is being discussed as a potential treatment for hair loss. Specific treatments mentioned include Minoxidil, Finasteride, and RU58841.

community Injections of follistatin and growth factors shown to improve hair growth in study

6 upvotes 12 years ago

Injections of follistatin and growth factors can improve hair growth. Specific treatments discussed include Minoxidil, finasteride, and RU58841.

community Hair Regrowth Following a Wnt- and Follistatin- Containing Treatment: Safety and Efficacy in a First-in-Man Phase 1 Clinical Trial: Scientific, Peer-Reviewed Dermatology Article Indexed with MEDLINE/PubMed

4 upvotes 10 years ago

A treatment containing Wnt and Follistatin was found to be safe and effective for hair regrowth in a Phase 1 clinical trial. Specific treatments discussed include Minoxidil, Finasteride, and RU58841.