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    Glossary Follistatin

    protein that inhibits activins, influencing muscle growth and hair

    Follistatin, also known as FS or FST, is a protein that plays a crucial role in regulating various biological processes by binding to and inhibiting members of the TGF-beta superfamily, particularly activins. This inhibition is important for controlling muscle growth, inflammation, and tissue repair. In the context of hair biology, follistatin has been studied for its potential to promote hair growth and counteract conditions like alopecia by modulating the activity of growth factors involved in hair follicle development.

    Learn 1

    1. Follistatin Protein that blocks activin, a growth-regulating signal

    Research 10 of 298

    1. Impaired wound healing in transgenic mice overexpressing the activin antagonist follistatin in the epidermis EMBO journal · 2001 · 163 citations
    2. Control of pelage hair follicle development and cycling by complex interactions between follistatin and activin The FASEB Journal · 2003 · 81 citations
    3. Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4 Journal of Investigative Dermatology · 2014 · 75 citations
    4. The activin binding proteins follistatin and follistatin-related protein are differentially regulated in vitro and during cutaneous wound repair 2001 · 46 citations
    5. The role of activins and follistatins in skin and hair follicle development and function Cytokine & Growth Factor Reviews · 2008 · 45 citations
    6. GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells 2008 · 39 citations
    7. Keratinocyte-derived follistatin regulates epidermal homeostasis and wound repair Laboratory investigation · 2008 · 28 citations
    8. Sp6 downregulation of follistatin gene expression in ameloblasts Journal of medical investigation · 2008 · 28 citations
    9. Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea Science Advances · 2022 · 16 citations
    10. Hair regrowth following a Wnt- and follistatin containing treatment: safety and efficacy in a first-in-man phase 1 clinical trial. PubMed · 2011 · 16 citations
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    Community 2

    1. Follistatin, thoughts about a potential treatment ? Reddit · 10 Sept 2023
    2. Hair Regrowth Following a Wnt- and Follistatin- Containing Treatment: Safety and Efficacy in a First-in-Man Phase 1 Clinical Trial: Scientific, Peer-Reviewed Dermatology Article Indexed with MEDLINE/PubMed Reddit · 4 Jun 2014