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    Glossary Follistatin

    protein that inhibits activins, influencing muscle growth and hair

    Follistatin, also known as FS or FST, is a protein that plays a crucial role in regulating various biological processes by binding to and inhibiting members of the TGF-beta superfamily, particularly activins. This inhibition is important for controlling muscle growth, inflammation, and tissue repair. In the context of hair biology, follistatin has been studied for its potential to promote hair growth and counteract conditions like alopecia by modulating the activity of growth factors involved in hair follicle development.

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    1. Impaired wound healing in transgenic mice overexpressing the activin antagonist follistatin in the epidermis EMBO journal · 2001 · 163 citations
    2. Control of pelage hair follicle development and cycling by complex interactions between follistatin and activin The FASEB Journal · 2003 · 81 citations
    3. Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4 Journal of Investigative Dermatology · 2014 · 75 citations
    4. The activin binding proteins follistatin and follistatin-related protein are differentially regulated in vitro and during cutaneous wound repair 2001 · 46 citations
    5. The role of activins and follistatins in skin and hair follicle development and function Cytokine & Growth Factor Reviews · 2008 · 45 citations
    6. GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells 2008 · 39 citations
    7. Keratinocyte-derived follistatin regulates epidermal homeostasis and wound repair Laboratory investigation · 2008 · 28 citations
    8. Sp6 downregulation of follistatin gene expression in ameloblasts Journal of medical investigation · 2008 · 28 citations
    9. Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea Science Advances · 2022 · 16 citations
    10. Hair regrowth following a Wnt- and follistatin containing treatment: safety and efficacy in a first-in-man phase 1 clinical trial. PubMed · 2011 · 16 citations
    11. A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea eLife · 2019 · 15 citations
    12. Too Many Follistatins: Racing Inside and Getting Out of the Cell Endocrinology · 2005 · 13 citations
    13. Immunohistochemical expression of cytokeratin 15, cytokeratin 19, follistatin, and Bmi-1 in basal cell carcinoma International Journal of Dermatology · 2015 · 10 citations
    14. Follistatin and secreted frizzled-related protein 1, OVO homolog-like 1-regulated genes, are important for hair follicle neogenesis Experimental Dermatology · 2015 · 4 citations
    15. Faculty Opinions recommendation of A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2019
    16. Author response: A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea 2019
    17. Decision letter: A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea 2019
    18. Faculty Opinions recommendation of Hair regrowth following a Wnt- and follistatin containing treatment: safety and efficacy in a first-in-man phase 1 clinical trial. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2012
    19. Activin A and Follistatin influence hair follicle development in mice 2007
    20. Hair growth control by follistatin Enshou saisei · 2004
    21. Secreted Frizzled‐Related Protein 2 ( SFRP2 ) Induces Follistatin‐Like 1 ( FSTL1 ) to Regulate Dihydrotestosterone ( DHT )‐Induced Dermal Papilla Cell Mitochondrial Dysfunction and Senescence Aging Cell · 2026
    22. Characterization and isolation of stem cell-enriched human hair follicle bulge cells 2005 · 550 citations
    23. Activin Controls Skin Morphogenesis and Wound Repair Predominantly via Stromal Cells and in a Concentration-Dependent Manner via Keratinocytes ˜The œAmerican journal of pathology · 2005 · 81 citations
    24. State-dependent signaling by Ca<sub>v</sub>1.2 regulates hair follicle stem cell function Genes & development · 2013 · 27 citations
    25. Polymorphisms of FST gene and their association with wool quality traits in Chinese Merino sheep PloS one · 2017 · 25 citations
    26. Alteration of Skin Wound Healing in Keratinocyte-Specific Mediator Complex Subunit 1 Null Mice PloS one · 2014 · 20 citations
    27. Telomere dysfunction impairs epidermal stem cell specification and differentiation by disrupting BMP/pSmad/P63 signaling PLOS genetics · 2019 · 19 citations
    28. Cyclosporine A stimulated hair growth from mouse vibrissae follicles in an organ culture model Journal of Nanjing Medical University · 2012 · 11 citations
    29. Tissue Mechanics in Haired Murine Skin: Potential Implications for Skin Aging Frontiers in Cell and Developmental Biology · 2021 · 9 citations
    30. Identification of key genes and signaling pathways related to Hetian sheep wool density by RNA-seq technology PLOS ONE · 2022 · 7 citations