Follistatin Promotes LIN28B-Mediated Supporting Cell Reprogramming and Hair Cell Regeneration in the Murine Cochlea

    February 2022 in “ Science Advances ”
    Xiao‐Jun Li, C. Lloyd Morgan, Loyal A. Goff, Angelika Doetzlhofer
    Studysummary This study found that coactivating LIN28B and follistatin enhances cochlear supporting cells' ability to regenerate hair cells in neonatal mice by reprogramming them into progenitor-like cells.
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    Research cited in this study 3

    1. A Counter Gradient of Activin A and Follistatin Instructs the Timing of Hair Cell Differentiation in the Murine Cochlea eLife · 2019
    2. Activin/Nodal Signaling in Stem Cells Development · 2015
    3. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012

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    1. Follistatin Promotes LIN28B-Mediated Supporting Cell Reprogramming and Hair Cell Regeneration in the Murine Cochlea Science Advances · 2022