Faculty Opinions Recommendation of Hair Regrowth Following a Wnt- and Follistatin-Containing Treatment: Safety and Efficacy in a First-in-Man Phase 1 Clinical Trial

    July 2012 in “ Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ”
    Rachita Dhurat, Sukesh M.S
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    TLDR New treatment with Wnt proteins and growth factors safely increases hair thickness.
    The study conducted by Zimber MP et al., published in 2011, explored a new understanding of the pathogenesis of androgenic alopecia (AGA) and a potential treatment method. Previously, AGA was believed to evolve from multiple gene involvement and androgen-mediated processes, with anti-androgens like finasteride used to reverse the process. However, this study examined the role of Wnt proteins and growth factors in stimulating hair growth. A single intradermal injection containing Wnt proteins and wound growth factors was administered to 26 subjects. After 12 weeks, a significant increase in hair shaft thickness and diversity was observed compared to a placebo, with no adverse events reported. The method for determining the optimal concentration of growth factors used in the study was not explained.
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