GLI2-Specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells

    March 2008 in “ Journal of biological chemistry/˜The œJournal of biological chemistry ”
    Thomas Eichberger, Alexandra Kaser, Claudia Pixner … Anna‐Maria Frischauf
    Studysummary This study found that GLI2 plays a key role in activating follistatin, an activin/BMP antagonist, in response to hedgehog signaling in human epidermal cells, with implications for hair follicle development and basal cell carcinoma.
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    Research cited in this study 8

    1. Scratching the Surface of Skin Development Nature · 2007
    2. Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes Molecular and Cellular Biology · 2006
    3. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    4. BMP Signaling in the Control of Skin Development and Hair Follicle Growth Differentiation · 2004
    5. GLI2 Is Expressed in Normal Human Epidermis and Basal Cell Carcinoma and Induces GLI1 Expression by Binding to Its Promoter Journal of Investigative Dermatology · 2004
    6. Control of Pelage Hair Follicle Development and Cycling by Complex Interactions Between Follistatin and Activin The FASEB Journal · 2003
    7. Induction of Basal Cell Carcinomas and Trichoepitheliomas in Mice Overexpressing GLI-1 Proceedings of the National Academy of Sciences · 2000
    8. Activation of the Transcription Factor Gli1 and the Sonic Hedgehog Signaling Pathway in Skin Tumors Nature · 1997