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GlossaryBasal Cell Carcinoma (BCC)

most common skin cancer, originating in basal epidermal cells

Basal Cell Carcinoma (BCC) is the most common type of skin cancer, originating in the basal cells, which are found in the deepest layer of the epidermis. It typically appears as a small, shiny bump or nodule on sun-exposed areas of the skin, such as the face and neck, and is usually caused by long-term exposure to ultraviolet (UV) radiation from the sun or tanning beds. While BCC rarely metastasizes, it can cause significant local damage if not treated promptly.

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research GLI2 Is Expressed in Normal Human Epidermis and Basal Cell Carcinoma and Induces GLI1 Expression by Binding to Its Promoter

171 citations , June 2004 in “Journal of Investigative Dermatology”

GLI2 activates GLI1, promoting skin tumor growth and hair development.

DMBA/TPA Treatment Is Necessary for Basal Cell Carcinoma Formation from Patched Deficient Epidermal Cells in Ptch Flox/Flox CD4Cre +/- Mice

research DMBA/TPA Treatment Is Necessary for Basal Cell Carcinoma Formation from Patched Deficient Epidermal Cells in Ptch Flox/Flox CD4Cre +/- Mice

11 citations , March 2014 in “Journal of Investigative Dermatology”

Genetic mutation and carcinogen treatment are both needed for skin cancer to develop in these specific mice.

research Use of Ultra-Fast One-Step CK5 IHC for Identifying BCC and SCC During Mohs Surgery

1 citations , April 2017 in “Journal of Investigative Dermatology”

A new one-step test can quickly identify skin cancer during surgery.

A Monoclonal Antibody Established from the Immunization of Basal Cell Carcinoma Tissues Reacts to the Intercellular Space of Basal Cell Carcinoma and Hair Follicles

research A Monoclonal Antibody Established from the Immunization of Basal Cell Carcinoma Tissues Reacts to the Intercellular Space of Basal Cell Carcinoma and Hair Follicles

1 citations , November 2002 in “Journal of dermatology”

The antibody created from BCC tissues reacts similarly to both BCC and hair follicles, suggesting BCC may come from hair follicle cells.

research Identification of the Cell Lineage at the Origin of Basal Cell Carcinoma

351 citations , February 2010 in “Nature Cell Biology”

Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.

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community Started my treatment 2 months ago, wanted to share some progress pictures and regime. What do you guys think?

in Progress Pictures 44 upvotes 2 years ago

PreparationAbject378 has been following a comprehensive regime of medications and lifestyle changes for the past two months to help with hair loss, including Dut, Minoxidil, Finasteride, RU58841, Keto shampoo, Derma pen, a running routine, diet modifications and supplements.

community "Creatine causes hair loss" myth debunked once and for all

in Research/Science 20 upvotes 3 years ago

Creatine does not directly cause hair loss but may increase DHT levels, potentially worsening hair loss in those predisposed to male pattern baldness. Users have mixed experiences, with some reporting increased shedding and others seeing no effect.

community Vitamin D - I was taking vitamin D last 6 month, my hair is back(4000UI daily)

in Progress Pictures 566 upvotes 2 years ago

User took vitamin D for 6 months and experienced hair regrowth. Others suggest comparing hair at the same length and lighting for accurate results.