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    Are Hair Follicle Stem Cells Promising Candidates for Wound Healing?

    December 2018 in “ Expert Opinion on Biological Therapy ”
    Bingmin Li, Wenzhi Hu, Kui Ma … Xiaobing Fu
    Studysummary This review discusses hair follicle stem cells for wound healing and reports no new clinical results, noting their potential but emphasizing the need for further understanding and safety in clinical applications.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 51

    1. Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate International Journal of Molecular Sciences · 2018
    2. Temporal Layering of Signaling Effectors Drives Chromatin Remodeling During Hair Follicle Stem Cell Lineage Progression Cell stem cell · 2018
    3. Epithelial-To-Mesenchymal Stem Cell Transition In A Human Organ: Lessons From Lichen Planopilaris Journal of Investigative Dermatology · 2017
    4. Concise Review: Wnt Signaling Pathways in Skin Development and Epidermal Stem Cells Stem cells · 2017
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    6. Secretory Phospholipase A2-IIA Overexpressing Mice Exhibit Cyclic Alopecia Mediated Through Aberrant Hair Shaft Differentiation and Impaired Wound Healing Response Scientific Reports · 2017
    7. Regulating Hair Follicle Stem Cells Immunity · 2017
    8. Characterization of Cell Cycle Arrest and Terminal Differentiation in a Maximally Proliferative Human Epithelial Tissue: Lessons from the Human Hair Follicle Matrix European Journal of Cell Biology · 2017
    9. VEGF165 Induces Differentiation of Hair Follicle Stem Cells Into Endothelial Cells and Plays a Role in In Vivo Angiogenesis Journal of Cellular and Molecular Medicine · 2017
    10. Wnt/β-Catenin Pathway in Tissue Injury: Roles in Pathology and Therapeutic Opportunities for Regeneration The FASEB Journal · 2016
    11. Regeneration of Hair and Other Skin Appendages: A Microenvironment-Centric View Wound Repair and Regeneration · 2016
    12. Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity Cell reports · 2016
    13. Hair Follicle and Interfollicular Epidermal Stem Cells Make Varying Contributions to Wound Regeneration Cell Cycle · 2015
    14. Somatic Stem Cell Heterogeneity: Diversity in the Blood, Skin, and Intestinal Stem Cell Compartments Nature Reviews Molecular Cell Biology · 2015
    15. Mapping the Expression of Epithelial Hair Follicle Stem Cell-Related Transcription Factors LHX2 and SOX9 in the Human Hair Follicle Experimental Dermatology · 2015
    16. Ceramide Synthase 4 Regulates Stem Cell Homeostasis And Hair Follicle Cycling Journal of Investigative Dermatology · 2015
    17. Culture and Characterization of Rat Hair Follicle Stem Cells Cytotechnology · 2014
    18. Gelatin-Chondroitin-6-Sulfate-Hyaluronic Acid Scaffold Seeded with Vascular Endothelial Growth Factor 165 Modified Hair Follicle Stem Cells as a Three-Dimensional Skin Substitute Stem cell research & therapy · 2014
    19. Alteration of Skin Wound Healing in Keratinocyte-Specific Mediator Complex Subunit 1 Null Mice PloS one · 2014
    20. Emerging Interactions Between Skin Stem Cells and Their Niches Nature Medicine · 2014
    21. Reflections on How Wound Healing-Promoting Effects of the Hair Follicle Can Be Translated into Clinical Practice Experimental Dermatology · 2014
    22. Leptin Controls Hair Follicle Cycling Experimental Dermatology · 2014
    23. Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges BioEssays · 2014
    24. In Vivo Transcriptional Governance of Hair Follicle Stem Cells by Canonical Wnt Regulators Nature Cell Biology · 2014
    25. Activated Hair Follicle Stem Cells and Wnt/β-Catenin Signaling Involved in Pathogenesis of Sebaceous Neoplasms International Journal of Medical Sciences · 2014
    26. Stem Cell Quiescence Acts as a Tumor Suppressor in Squamous Tumors Nature Cell Biology · 2013
    27. Hair Cycle Control by Leptin as a New Anagen Inducer Experimental Dermatology · 2013
    28. Differentiation of Human Hair Follicle Stem Cells Into Endothelial Cells Induced by Vascular Endothelial and Basic Fibroblast Growth Factors Molecular Medicine Reports · 2013
    29. Augmenting Endogenous Wnt Signaling Improves Skin Wound Healing PLoS ONE · 2013
    30. Spatial Organization Within a Niche as a Determinant of Stem-Cell Fate Nature · 2013
    31. Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding Nature Medicine · 2013
    32. Therapeutic Strategy for Hair Regeneration: Hair Cycle Activation, Niche Environment Modulation, Wound-Induced Follicle Neogenesis, and Stem Cell Engineering Expert Opinion on Biological Therapy · 2013
    33. Competitive Balance of Intrabulge BMP/Wnt Signaling Reveals a Robust Gene Network Ruling Stem Cell Homeostasis and Cyclic Activation Proceedings of the National Academy of Sciences · 2013
    34. A Pilot Clinical Study of Hair Grafting in Chronic Leg Ulcers Wound Repair and Regeneration · 2012
    35. Epithelial Stem Cells And Implications For Wound Repair Seminars in Cell & Developmental Biology · 2012
    36. Roles of MED1 in Quiescence of Hair Follicle Stem Cells and Maintenance of Normal Hair Cycling ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2012
    37. Wnt Signaling and Injury Repair Cold Spring Harbor Perspectives in Biology · 2012
    38. TCF/Lef1 Activity Controls Establishment of Diverse Stem and Progenitor Cell Compartments in Mouse Epidermis The EMBO Journal · 2011
    39. Targeted Inactivation of Integrin-Linked Kinase in Hair Follicle Stem Cells Reveals an Important Modulatory Role in Skin Repair After Injury Molecular Biology of the Cell · 2011
    40. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011
    41. Dynamic Plasticity of Axons Within a Cutaneous Milieu Journal of Neuroscience · 2010
    42. Hedgehog Signaling Maintains Hair Follicle Stem Cell Phenotype in Young and Aged Human Skin Aging Cell · 2009
    43. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    44. An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell Contribution ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2007
    45. Adult Bone-Marrow-Derived Mesenchymal Stem Cells Contribute to Wound Healing of Skin Appendages Cell and Tissue Research · 2006
    46. The Cell-Surface Marker MTS24 Identifies a Novel Population of Follicular Keratinocytes With Characteristics of Progenitor Cells Development · 2006
    47. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    48. Long-Term Renewal of Hair Follicles from Clonogenic Multipotent Stem Cells Proceedings of the National Academy of Sciences of the United States of America · 2005
    49. Transient Activation of Beta-Catenin Signaling in Adult Mouse Epidermis Induces New Hair Follicles, Continuous Activation Maintains Tumors Development · 2004
    50. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    51. Keratin 19 as a Biochemical Marker of Skin Stem Cells In Vivo and In Vitro: Localization and Variation with Age and Culture Stage Journal of Cell Science · 1996

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