Roles of MED1 in Quiescence of Hair Follicle Stem Cells and Maintenance of Normal Hair Cycling

    August 2012 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Takeshi Nakajima, Shigeki Inui, Tomohiro Fushimi … Satoshi Itami
    Studysummary This study found that MED1 plays a role in maintaining keratinocyte quiescence and hair follicle stem cell populations, as its absence in mice led to increased keratinocyte proliferation and reduced stem cell numbers.
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    Research cited in this study 11

    1. Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alterations ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2011
    2. Hedgehog Signaling Maintains Hair Follicle Stem Cell Phenotype in Young and Aged Human Skin Aging Cell · 2009
    3. Bone Morphogenetic Protein Antagonist Noggin Promotes Skin Tumorigenesis Via Stimulation Of The Wnt And Shh Signaling Pathways American Journal Of Pathology · 2009
    4. The Human Keratins: Biology And Pathology Histochemistry and Cell Biology · 2008
    5. Mutations in the Serum/Glucocorticoid Regulated Kinase 3 (SGK3) Are Responsible for the Mouse Fuzzy (FZ) Hair Phenotype Journal of Investigative Dermatology · 2007
    6. Vitamin D Receptor Is Essential For Normal Keratinocyte Stem Cell Function Proceedings of the National Academy of Sciences · 2007
    7. Development and Progression of Alopecia in the Vitamin D Receptor Null Mouse Journal of cellular physiology · 2006
    8. Premature Termination of Hair Follicle Morphogenesis and Accelerated Hair Follicle Cycling in Iasi Congenital Atrichia (fzica) Mice Points to Fuzzy as a Key Element of Hair Cycle Control Experimental dermatology · 2005
    9. Morpho-Regulation of Ectodermal Organs ˜The œAmerican journal of pathology · 2004
    10. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    11. Cyclic Alopecia in Msx2 Mutants: Defects in Hair Cycling and Hair Shaft Differentiation Development · 2002

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