Mutations in the Serum/Glucocorticoid Regulated Kinase 3 (SGK3) Are Responsible for the Mouse Fuzzy (FZ) Hair Phenotype

    October 2007 in “ Journal of Investigative Dermatology ”
    Dean R. Campagna, Ángel O. Custodio, Brendan Antiochos, Marius V. Cirlan, Mark D. Fleming
    TLDR Mutations in the Sgk3 gene cause fuzzy hair in mice.
    The study identified mutations in the Serum/Glucocorticoid Regulated Kinase 3 (Sgk3) gene as responsible for the fuzzy (fz) hair phenotype in mice, characterized by sparse and curly fur. Researchers discovered a new allele of fz in a genome-wide screen of 108 affected mice, pinpointing a deletion in the Sgk3 gene that truncates the protein, affecting hair follicle development. The study linked this mutation to other known fz alleles, demonstrating that Sgk3 plays a crucial role in hair follicle cell proliferation, differentiation, and migration. This research highlighted the importance of Sgk3 in hair follicle biology and the potential of spontaneous mouse mutants in genetic studies.
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