The Critical Roles of Serum/Glucocorticoid-Regulated Kinase 3 (SGK3) in Hair Follicle Morphogenesis and Homeostasis
April 2006
in “
American Journal of Pathology
”
Serum/Glucocorticoid-Regulated Kinase 3 SGK3 hair follicle morphogenesis hair follicle homeostasis Sgk3 mutant hair matrix keratinocytes anagen phase phosphorylation GSK3B β-catenin WNT-β-catenin pathway hair growth hair cycle hair development hair cells growth phase protein phosphorylation beta-catenin WNT pathway
TLDR SGK3 is essential for proper hair growth and health.
The document from April 2006 presents a study on the role of Serum/Glucocorticoid-Regulated Kinase 3 (SGK3) in hair follicle development and homeostasis in Sgk3 mutant YPC mice. The study found that mutations in the Sgk3 gene led to defective hair follicle development, with aberrant differentiation and reduced proliferation of hair matrix keratinocytes, resulting in weak hair and a shortened anagen phase. The study also observed reduced phosphorylation of GSK3B and decreased nuclear accumulation of β-catenin, implicating the WNT-β-catenin pathway in SGK3-dependent hair follicle development. The findings suggest that SGK3 is critical for hair follicle morphogenesis and cycling, and the YPC mice serve as a useful model for studying these processes. The number of mice used in the study was not specified.
