The Critical Roles of Serum/Glucocorticoid-Regulated Kinase 3 (SGK3) in Hair Follicle Morphogenesis and Homeostasis

    April 2006 in “ American Journal of Pathology ”
    Taro Okada, Yoshiyuki Ishii, Kentaro Masujin … Kunio Doi
    Studysummary This study found that mutations in the Sgk3 gene cause defective hair follicle development and altered hair cycling in mice, with variable phenotypic outcomes depending on different dysfunction patterns of the SGK3 protein.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on ajp.amjpathol.org →
    Discuss this study in the Community →

    Research cited in this study 18

    1. Sgk3 Links Growth Factor Signaling to Maintenance of Progenitor Cells in the Hair Follicle The Journal of Cell Biology · 2005
    2. Bone Morphogenetic Protein Signaling Regulates Postnatal Hair Follicle Differentiation and Cycling ˜The œAmerican journal of pathology · 2004
    3. A Mutation in the Serum and Glucocorticoid-Inducible Kinase-Like Kinase (SGKL) Gene Is Associated with Defective Hair Growth in Mice DNA Research · 2004
    4. Defining BMP Functions in the Hair Follicle by Conditional Ablation of BMP Receptor IA The Journal of Cell Biology · 2003
    5. Bone Morphogenetic Proteins and Their Antagonists in Skin and Hair Follicle Biology Journal of Investigative Dermatology · 2003
    6. Cyclic Alopecia in Msx2 Mutants: Defects in Hair Cycling and Hair Shaft Differentiation Development · 2002
    7. Age-Related Changes in the Dorsal Skin Histology in Mini and Wistar Rats PubMed · 2002
    8. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    9. Mutant Laboratory Mice With Abnormalities in Hair Follicle Morphogenesis, Cycling, and Structure: Annotated Tables Experimental dermatology · 2001
    10. Inhibition of BMP Signaling Affects Growth and Differentiation in the Anagen Hair Follicle The EMBO Journal · 2000
    11. Conditional Disruption of Hedgehog Signaling Pathway Defines Its Critical Role in Hair Development and Regeneration Journal of Investigative Dermatology · 2000
    12. Insulin-Like Growth Factor 1 and Hair Growth Dermatology Online Journal · 1999
    13. Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation Development · 1999
    14. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    15. The Role of the Hairless (Hr) Gene in the Regulation of Hair Follicle Catagen Transformation American Journal Of Pathology · 1999
    16. WNT Signaling in the Control of Hair Growth and Structure Developmental biology · 1999
    17. Angora Mouse Mutation: Altered Hair Cycle, Follicular Dystrophy, Phenotypic Maintenance of Skin Grafts, and Changes in Keratin Expression Veterinary Pathology · 1997
    18. Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins ˜The œjournal of cell biology/˜The œJournal of cell biology · 1986