Altered Hair Root Gene Expression Profiles Highlight Calcium Signaling and Lipid Metabolism Pathways Associated With Curly Hair Initiation and Maintenance in Mangalitza Pigs

June 2023 in “ Frontiers in Genetics ”

Nadia Khaveh, Kathrin Schachler, Jan Berghöfer, Klaus Jung, Julia Metzger

calcium signaling lipid metabolism RNA sequencing gene expression differentially expressed genes ionic calcium-dependency TRPM2 CYP4F3

Studysummary This study suggests that the curly hair phenotype in Mangalitza pigs may involve complex gene interactions related to calcium signaling and lipid metabolism, rather than changes in TRPM2 or CYP4F3 expression.

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The research paper investigated the genetic basis of curly hair in Mangalitza pigs, using RNA sequencing to analyze gene expression in hair roots. The study found 2,554 significant differentially expressed genes (DEGs) between curly and straight hair, with 2,036 of these DEGs being upregulated and 518 DEGs being downregulated in curly-haired individuals. The study highlighted the importance of calcium signaling and lipid metabolism pathways in the development and maintenance of curly hair. The study also suggested an ionic calcium-dependency as a prominent factor for the maintenance of this phenotype. The research did not identify TRPM2 or CYP4F3, previously suggested genes, as differentially expressed, but found their associated genes and proteins to interact with lipids and calcium-related pathways.

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