Altered Hair Root Gene Expression Profiles Highlight Calcium Signaling and Lipid Metabolism Pathways Associated With Curly Hair Initiation and Maintenance in Mangalitza Pigs

    June 2023 in “ Frontiers in Genetics
    Nadia Khaveh, Kathrin Schachler, Jan Berghöfer, Klaus Jung, Julia Metzger
    Image of study
    TLDR Genes related to calcium signaling and lipid metabolism are important for curly hair in Mangalitza pigs.
    The research paper investigated the genetic basis of curly hair in Mangalitza pigs, using RNA sequencing to analyze gene expression in hair roots. The study found 2,554 significant differentially expressed genes (DEGs) between curly and straight hair, with 2,036 of these DEGs being upregulated and 518 DEGs being downregulated in curly-haired individuals. The study highlighted the importance of calcium signaling and lipid metabolism pathways in the development and maintenance of curly hair. The study also suggested an ionic calcium-dependency as a prominent factor for the maintenance of this phenotype. The research did not identify TRPM2 or CYP4F3, previously suggested genes, as differentially expressed, but found their associated genes and proteins to interact with lipids and calcium-related pathways.
    Discuss this study in the Community →

    Research cited in this study

    19 / 19 results

    Related Community Posts Join

    6 / 107 results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  42 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community New Treatments, and a Huge Group Buy with Lots of Research

      in Research/Science  109 upvotes 1 year ago
      A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

      community Why is human evolution like this 😂

      in Chat 2 years ago
      Why androgenic alopecia affects the scalp rather than other body parts, potential explanations for this phenomenon, treatments available to combat hair loss, and the implications of male attractiveness in modern society.

      community biotin leads to acne and sebum on scalp ??

      in Finasteride/Dutasteride  1 upvotes 7 months ago
      User is experiencing increased sebum, dandruff, and acne after taking a supplement containing biotin, iron, zinc, and calcium pantothenate along with finasteride. They are questioning if biotin is the cause and whether they should stop taking it.

    Related Research

    4 / 4 results