Integrated Analysis of Methylome and Transcriptome Changes Reveals the Underlying Regulatory Signatures Driving Curly Wool Transformation in Chinese Zhongwei Goats

January 2020 in “ Frontiers in Genetics ”

Ping Xiao, Tao Zhong, Zhanfa Liu, Yangyang Ding, Weijun Guan, Xiaohong He, Yabin Pu, Lin Jiang, Yuehui Ma, Qianjun Zhao

DNA methylation gene expression differentially methylated regions intercellular communication cytoskeleton epigenetic mechanisms PDGFC hair follicle-related genes

TLDR PDGFC gene may help select goats with desirable curly wool traits.

The study investigated the molecular mechanisms behind curly wool transformation in Chinese Zhongwei goats by analyzing DNA methylation and gene expression changes. Researchers used whole genome bisulfite sequencing and RNA sequencing on skin samples from goats at 45 and 108 days old, identifying 326 differentially expressed genes (DEGs) and 3,379 differentially methylated regions (DMRs). Key findings included the role of the PDGFC gene in promoting hair follicle cell growth and its involvement in significant pathways like the epidermal growth factor receptor (EGFR) and transforming growth factor beta (TGF-beta) signaling. The study highlighted the importance of epigenetic processes in hair development, providing insights that could be relevant to understanding hair characteristics in humans.

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