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GlossaryEpigenetic Regulation (Epigenetic Mechanisms)

chemical modifications that turn genes on or off

Epigenetic Regulation refers to the process by which genes are turned on or off without changing the underlying DNA sequence. This is achieved through chemical modifications, such as DNA methylation and histone modification, which can influence gene expression and, consequently, cellular function. These changes can be influenced by environmental factors and can be heritable, playing a crucial role in development, disease, and adaptation.

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All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

research All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

January 2018 in “Stem cell biology and regenerative medicine”

The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.

research Second International Symposium: Epigenetic Regulation of Skin Regeneration and Aging

2 citations , June 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

Epigenetic factors play a crucial role in skin health and disease.

research Dynamics and Epigenetics of the Epidermal Differentiation Complex

February 2024 in “Epigenomes”

Epigenetic mechanisms control skin development by regulating gene expression.

research Principles and Mechanisms of Regeneration in the Mouse Model for Wound-Induced Hair Follicle Neogenesis

46 citations , March 2015 in “Regeneration”

Mice can grow new hair follicles after skin wounds through a process not involving existing hair stem cells, but requiring more research to understand fully.

research Epigenetic Mechanism of Gtl2-miRNAs Causes the Primitive Sheep Characteristics Found in Purebred Merino Sheep

October 2023 in “Cell & bioscience”

A special gene region controls the re-emergence of a primitive wool type in Merino sheep, improving their wool yield and adaptability.

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community Bruteforcing alopecia or the new advent of science progress

in Research/Science 19 upvotes 9 months ago

Combining therapies like scyllo-inositol, alpha-ketoglutarate, and autophagy-inducing supplements may enhance hair growth and prevent hair loss. Reporting individual results can accelerate progress in hair loss treatments.

community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

in Research/Science 14 upvotes 1 year ago

NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 year ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community Two Great Articles on NCBI That Summarize What We Actually Know About Finasteride Side Effects

in Finasteride 80 upvotes 6 years ago

The side effects of taking finasteride as a treatment for hair loss, with particular focus on its sexual and psychiatric side effects; research has indicated that there are high and low outliers in terms of prevalence of sexual side effects, but it is usually between 3-5%, while evidence of lasting sexual side effects comes from lower quality sources.

community Do you think people of previous generations had better hair? What changed?

in Chat 2146 upvotes 3 weeks ago

Hair loss is less common now due to accessible treatments like finasteride, minoxidil, and hair transplants. Improved hair care, skincare, and lifestyle changes contribute to people looking younger today.

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