Trazodone By Epigenetic Mechanism Can Reverse The Post Finasteride Syndrome
November 2023
in “
Magna Scientia Advanced Research and Reviews
”
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Studysummary The researchers proposed that an epigenetic change in brain androgen receptors caused by finasteride could lead to post finasteride syndrome, while trazodone might reverse this effect by altering the epigenetic expression related to erection and libido.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study suggests that finasteride, by inhibiting the 5alpha-reductase enzyme in the brain, may cause epigenetic changes in the androgen receptor's mRNA, leading to post finasteride syndrome. This syndrome is theorized to result from an imbalance in histone acetylation and methylation due to altered levels of DHT and free testosterone. Trazodone, with its alpha-adrenergic antagonist properties, might reverse these epigenetic changes in neuronal circuits, potentially alleviating symptoms related to erection and libido affected by finasteride.
