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Glossary Free Testosterone

unbound testosterone available for immediate use by tissues

Free Testosterone refers to the fraction of testosterone in the bloodstream that is not bound to proteins like sex hormone-binding globulin (SHBG) or albumin. This unbound testosterone is biologically active and readily available for tissues to use, playing a crucial role in various bodily functions such as muscle growth, mood regulation, and sexual health.

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Research

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research Free Testosterone: Pumping up the Tires or Ending the Free Ride?

78 citations , August 2017 in “Endocrine Reviews”

This review discusses the free hormone hypothesis for measuring "free" testosterone and critiques its theoretical basis and clinical application, noting it lacks critical empirical testing and has inconsistent utility in assessing androgen status.

research Elevated Free Testosterone Levels in Women With Acne

56 citations , October 1983 in “Archives of Dermatology”

This study found that free testosterone levels were a more sensitive indicator of hyperandrogenism in women with acne than total testosterone levels.

research Effect of finasteride 5 mg (Proscar) on acne and alopecia in female patients with normal serum levels of free testosterone

43 citations , January 2007 in “Gynecological Endocrinology”

This study found that 9 out of 12 women with acne or alopecia showed subjective improvement with finasteride treatment despite having normal free testosterone levels, suggesting a potential role of 5alpha-reductase activity.

research Is it Necessary to Measure Free Testosterone to Assess Hyperandrogenemia in Women? The Role of Calculated Free and Bioavailable Testosterone

22 citations , May 2006 in “Experimental and Clinical Endocrinology & Diabetes”

This study found that calculated parameters like free testosterone and bioavailable testosterone were higher in women with hirsutism and PCOS compared to controls, suggesting these might better assess hyperandrogenemia than measured hormone values.

research Triglycerides, independent of Ferriman Gallwey Score, is a main determinant of free testosterone index in PCOS

6 citations , January 2019 in “F1000Research”

This study found that triglycerides, testosterone, and SHBG levels were associated with hyperandrogenism in women with PCOS, while FGS was not linked to this condition.

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Community Join

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community Very high free testosterone on dut…

9 upvotes 6 months ago

The user has high free testosterone and is still experiencing hair loss despite taking dutasteride and oral minoxidil for over three years. They are considering adding a topical anti-androgen like RU58841.

community Does finasteride decrease free testosterone?

in Research/Science 186 upvotes 1 year ago

Finasteride may decrease free testosterone by increasing SHBG, potentially causing side effects like reduced libido and hormonal changes. Some find it effective for hair loss, while others experience negative effects.

community Is it a lot of free testosterone?

4 upvotes 1 year ago

The conversation discusses hair loss and the impact of testosterone and DHT levels, with suggestions to monitor these levels and consider vitamin D supplementation. Treatments mentioned include finasteride and possibly minoxidil.

community 13 Years Finasteride, Switched to Dutasteride - 25% increase in Total Testosterone (expected) but 150% increase in Free Testosterone?

27 upvotes 11 months ago

After switching from finasteride to dutasteride, the user experienced a 25% increase in total testosterone and a 150% increase in free testosterone, with side effects like brain fog and nipple tingling. The user plans to consult a lab for accuracy and adjust the dutasteride dosage to manage side effects.

community Thoughts on Pre-Finasteride Bloodwork? Normal/high Total and Free Testosterone, Low DHEA-S?

5 upvotes 4 years ago

A 23-year-old male is considering starting Finasteride for hair loss after experiencing persistent shedding and hairline recession, with bloodwork showing normal testosterone levels but low DHEA-S and Vitamin D. He plans to discuss DHEA supplementation with his doctor and has already started Vitamin D supplementation.

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