Epigenetic Mechanisms, Assessment and Therapeutics of Epidermal Stem Cells in Skin Aging

January 2025 in “ Stem Cells International ”

Jiayu Yang, Mohan Xu, Yiheng Duan, Yuhang Yuan, Jiaming Zhang, Wenqing Jiang

epigenetic modifications epidermal stem cells DNA methylation histone modifications noncoding RNA epigenetic clocks Horvath's clock VisAgeX biological age antiaging treatments dermatological therapies

Studysummary In this review, researchers discuss the role of epigenetic modifications in epidermal stem cells' decline during skin aging and identify potential interventions targeting these disruptions, suggesting significant possibilities for antiaging strategies and dermatological treatments.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document reviews the role of epigenetic mechanisms in the aging of epidermal stem cells (EpSCs) and their impact on skin aging. Epigenetic changes, such as DNA methylation and histone modifications, contribute to the decline in EpSCs' regenerative capacity, leading to thinner skin and slower wound healing. The review discusses epigenetic clocks for measuring cellular aging and explores therapeutic strategies to delay skin aging by targeting these changes. It highlights the importance of understanding molecular pathways affected by aging and environmental factors. Therapeutic strategies, including retinoids and DNMT1 inhibitors, show promise in reversing age-related shifts, while regenerative approaches like stem cell-derived exosomes offer antiaging benefits. Future research should focus on identifying specific epigenetic targets for personalized therapies and improving delivery systems.

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