Laminin 332 Is Indispensable for Homeostatic Epidermal Differentiation Programs
Laminin 332 epidermal homeostasis keratinocyte differentiation epidermal thickening blister formation keratins cellular stress markers actin cytoskeleton inflammatory response S100A8 S100A9 alarmins Lm332 skin homeostasis skin cell differentiation skin thickening skin blisters skin proteins stress markers cell structure inflammation
TLDR Laminin 332 is essential for normal skin cell behavior and structure.
The study demonstrates that Laminin 332 (Lm332) is essential for maintaining epidermal homeostasis and proper keratinocyte differentiation. Using Lama3e knockout mice, researchers observed significant epidermal thickening, blister formation, and altered gene expression, including upregulation of keratins and cellular stress markers. The absence of Lm332 led to disorganization of the actin cytoskeleton, changes in cell shape, and an inflammatory response marked by increased S100A8 and S100A9 alarmins. These findings underscore the critical role of Lm332 in epidermal integrity, signaling, and preventing cellular stress.
