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Glossary Skin Thickening

process where skin becomes thicker due to chronic irritation

Skin thickening, also known as lichenification, refers to the process where the skin becomes thicker and leathery due to chronic inflammation or repeated irritation. This condition often results from persistent scratching or rubbing, leading to an exaggerated skin cell production and a more pronounced skin texture. It is commonly seen in conditions like eczema or chronic dermatitis.

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Research

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research Single nucleotide polymorphisms in the KRT82 promoter region modulate irregular thickening and patchiness in the dorsal skin of New Zealand rabbits

2 citations , May 2024 in “BMC Genomics”

This study analyzed the genetics of the patchiness phenotype in New Zealand rabbits and found that the gene KRT82, with identified SNPs in its promoter, may serve as a potential biomarker for breeding these rabbits.

research Morphological analysis of patchy thickening and reddish discoloration of active hair growth areas in the skin of New Zealand White rabbits

6 citations , January 2017 in “Journal of toxicologic pathology”

This study suggests that the patchy thickening and reddish discoloration in rabbit skin during the hair cycle may be due to large anagen-phase hair follicles compressing the dermis and increased blood vessels causing redness.

research Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure.

252 citations , November 1995 in “The EMBO Journal”

Blocking EGFR in mice causes hair loss and skin changes.

research Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin

201 citations , May 2001 in “Proceedings of the National Academy of Sciences”

This study found that transgenic expression of COX-2 in mouse basal keratinocytes causes epidermal hyperplasia and certain dysplastic features at specific body sites.

research Inactivation of the Vitamin D Receptor Enhances Susceptibility of Murine Skin to UV-Induced Tumorigenesis

148 citations , May 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that mice lacking the vitamin D receptor (VDR) developed skin tumors more rapidly than those with normal VDR activity, regardless of 1,25-dihydroxyvitamin D(3) presence.

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Community Join

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community 23M – 107 days on dutasteride (0.5mg/day) + minoxidil. Any real progress or too early?

in Is this regrowth? 116 upvotes 9 months ago

A 23-year-old male has been using dutasteride (0.5mg daily) and minoxidil with tretinoin for 107 days to address crown hair loss, noticing slight thickening but uncertain progress. He reports no shedding or side effects, experiencing positive effects like improved skin texture and increased energy.

community Has anyone’s hair improved/saw more regrowth/thickening after quitting smoking cigarettes.

12 upvotes 2 months ago

Quitting smoking may improve hair quality and overall health, but it is not a standalone solution for reversing hair loss. Treatments like finasteride and minoxidil are more effective for hair regrowth, while smoking can exacerbate hair loss by increasing DHT and affecting scalp health.

community I saw results in just 10 days ..

in Minoxidil 6 upvotes 5 months ago

The user reported noticeable hair thickening after 10 days of using oral minoxidil and finasteride, but others suggested it might be an April Fool's joke or a placebo effect. The user also mentioned a high protein intake and regular gym workouts, while others discussed concerns about finasteride's side effects.

community Progress? 2 months topical 7% min and .1% dutasteride

in Is this regrowth? 27 upvotes 10 months ago

The user reported hair thickening after two months of using topical 7% minoxidil and 0.1% dutasteride, with no side effects. They previously experienced side effects with oral finasteride and switched to the topical treatment.

community Two full years on Fin and Min — I think I’ve made some progress

in Progress Pictures 138 upvotes 1 year ago

The user experienced hair thickening after two years of using finasteride and minoxidil, despite having a stubborn thin crown. They plan to try microneedling to potentially improve results further.

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Learn

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learn Melatonin

Can melatonin cause side effects on the skin or hair? Melatonin may cause hair loss or thinning in some users, but evidence is limited.

learn Scalp Micropigmentation

Does scalp micropigmentation work on all skin tones and hair colors? Scalp micropigmentation can be customized for various skin tones and hair colors.
Is scalp micropigmentation suitable for people with sensitive skin? Providers say scalp micropigmentation suits most skin types and describe patch tests, hypoallergenic pigments and a skin consultation for sensitive skin. These are provider claims rather than independent safety evidence, and pigment reactions remain a risk.

learn retinol

How does retinol improve scalp health and prepare the skin for other hair growth treatments? Retinol improves scalp health by promoting cellular turnover and reducing congestion.

learn Hyaluronic Acid

Does hyaluronic acid really hydrate the scalp, or is it mainly for skin care? Hyaluronic acid can hydrate the scalp, but its effectiveness may vary.

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Clinics

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Experts

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SMP Specialist
Noelle Skin
Nice, France

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Noelle Skin