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    Glossary Hyperkeratosis

    excessive thickening of skin's outer layer due to keratin

    Hyperkeratosis is a condition where the outer layer of the skin, known as the stratum corneum, becomes excessively thick due to an overproduction of keratin. This can result in rough, scaly patches on the skin and is often seen in conditions like psoriasis or eczema. For professionals, it is important to note that hyperkeratosis can be a response to chronic irritation or inflammation and may require targeted treatments to manage the underlying cause.

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    1. Loss of Keratin K2 Expression Causes Aberrant Aggregation of K10, Hyperkeratosis, and Inflammation 2014 · 32 citations
    2. Keratin pattern in hyperkeratotic and ulcerated gastric pars oesophagea in pigs 1997 · 13 citations
    3. [Dermatophytic disease: exuberant hyperkeratosis with cutaneous horns]. PubMed · 1998 · 6 citations
    4. A combination of low-dose systemic etretinate and topical calcipotriol/betamethasone dipropionate treatment for hyperkeratosis and itching in Olmsted syndrome associated with a TRPV3 mutation Journal of dermatological science · 2017 · 5 citations
    5. Resolution of the plantar hyperkeratosis of pachyonychia congenita during chemotherapy for Ewing sarcoma British Journal of Dermatology · 2013 · 2 citations
    6. 738 Cryo-EM and molecular dynamics of TRPV3 channel in activated state reveal structural features implicated in severe itch and hyperkeratosis 2023
    7. Zinc-responsive Acral Hyperkeratosis as a Sequele of Acrodermatitis Enteropathica Indian Journal of Paediatric Dermatology · 2025
    8. Follicular cysts and hyperkeratoses in early mycosis fungoides International Journal of Dermatology · 1998 · 3 citations
    9. Spiny Hyperkeratotic Projections on the Face and Extremities of a Kidney Transplant Recipient—Quiz Case Archives of dermatology · 2006 · 21 citations
    10. Pruritic Hyperkeratotic Facial Papules Archives of dermatology · 1997 · 1 citations
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