A Combination of Low-Dose Systemic Etretinate and Topical Calcipotriol/Betamethasone Dipropionate Treatment for Hyperkeratosis and Itching in Olmsted Syndrome Associated with a TRPV3 Mutation

May 2017 in “ Journal of dermatological science ”

Takuya Takeichi, Katsuhiko Tsukamoto, Yusuke Okuno, Daisuke Kojima, Michihiro Kono, Yasushi Suga, Masashi Akiyama

etretinate calcipotriol betamethasone dipropionate hyperkeratosis keratoderma TRPV3 mutation Dovonex Diprolene

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Studysummary This study reviewed the genetic and phenotypic aspects of Olmsted syndrome, highlighting pathogenic mutations in TRPV3 and MBTPS2 genes and their association with specific skin manifestations like symmetrical keratoderma and hyperkeratotic plaques. Our plain-language summary of this paper — not a Tressless recommendation.

The document discussed a treatment approach for Olmsted syndrome (OS), a rare genetic skin disorder characterized by symmetrical keratoderma and hyperkeratotic plaques, often associated with TRPV3 mutations. The study explored the efficacy of combining low-dose systemic etretinate with topical calcipotriol/betamethasone dipropionate to manage hyperkeratosis and itching in OS patients. This combination therapy aimed to alleviate the severe skin manifestations and improve the quality of life for individuals suffering from this condition.

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Research cited in this study

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research Two Familial Cases of Olmsted-Like Syndrome with a G573V Mutation of the TRPV3 Gene

12 citations , June 2016 in “Clinical and experimental dermatology”

This study reported a previously undescribed G573V point mutation in the TRPV3 gene as a cause of familial Olmsted syndrome in a Mongolian family.

research Expanding The Phenotypic Spectrum Of Olmsted Syndrome

27 citations , June 2015 in “Journal of Investigative Dermatology”

This study found that mutations in the TRPV3 gene can cause a broader range of symptoms in Olmsted syndrome than previously recognized, including severe palmoplantar keratoderma without other classic features.