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GlossaryKeratoderma

thickening of skin on palms and soles

Keratoderma refers to a group of skin conditions characterized by the thickening of the outer layer of the skin, particularly on the palms of the hands and the soles of the feet. This thickening is due to an overproduction of keratin, a key structural protein in the skin. It can be inherited or acquired and may be associated with other medical conditions.

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research Severe, Disfiguring, Pityriasis Rubra Pilaris in a Woman in the Dominican Republic

10 citations , October 2015 in “Journal of the International Association of Providers of AIDS Care”

A woman with HIV had a severe skin condition that improved with antiretroviral therapy.

research A Combination of Low-Dose Systemic Etretinate and Topical Calcipotriol/Betamethasone Dipropionate Treatment for Hyperkeratosis and Itching in Olmsted Syndrome Associated with a TRPV3 Mutation

5 citations , May 2017 in “Journal of dermatological science”

The combined treatment effectively managed severe skin issues in Olmsted syndrome.

research Olmsted Syndrome Caused by a Heterozygous p.Gly568Val Missense Mutation in TRPV3 Gene

13 citations , January 2018 in “Yonsei Medical Journal”

A specific gene mutation causes Olmsted syndrome.

Structural and Biochemical Changes Underlying a Keratoderma-Like Phenotype in Mice Lacking Suprabasal AP1 Transcription Factor Function

research Structural and Biochemical Changes Underlying a Keratoderma-Like Phenotype in Mice Lacking Suprabasal AP1 Transcription Factor Function

17 citations , February 2015 in “Cell Death and Disease”

Inhibiting AP1 in mice skin causes structural changes and weakens the skin barrier.

research Characterizing Disease Features and Other Medical Diagnoses in Patients With Pityriasis Rubra Pilaris

12 citations , September 2020 in “JAMA Dermatology”

PRP patients show varied symptoms and need more research to understand related conditions.

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