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    Glossary Hyperkeratosis

    excessive thickening of skin's outer layer due to keratin

    Hyperkeratosis is a condition where the outer layer of the skin, known as the stratum corneum, becomes excessively thick due to an overproduction of keratin. This can result in rough, scaly patches on the skin and is often seen in conditions like psoriasis or eczema. For professionals, it is important to note that hyperkeratosis can be a response to chronic irritation or inflammation and may require targeted treatments to manage the underlying cause.

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    Research 30 of 1000+

    1. Loss of Keratin K2 Expression Causes Aberrant Aggregation of K10, Hyperkeratosis, and Inflammation 2014 · 32 citations
    2. Keratin pattern in hyperkeratotic and ulcerated gastric pars oesophagea in pigs 1997 · 13 citations
    3. [Dermatophytic disease: exuberant hyperkeratosis with cutaneous horns]. PubMed · 1998 · 6 citations
    4. A combination of low-dose systemic etretinate and topical calcipotriol/betamethasone dipropionate treatment for hyperkeratosis and itching in Olmsted syndrome associated with a TRPV3 mutation Journal of dermatological science · 2017 · 5 citations
    5. Resolution of the plantar hyperkeratosis of pachyonychia congenita during chemotherapy for Ewing sarcoma British Journal of Dermatology · 2013 · 2 citations
    6. 738 Cryo-EM and molecular dynamics of TRPV3 channel in activated state reveal structural features implicated in severe itch and hyperkeratosis 2023
    7. Zinc-responsive Acral Hyperkeratosis as a Sequele of Acrodermatitis Enteropathica Indian Journal of Paediatric Dermatology · 2025
    8. Follicular cysts and hyperkeratoses in early mycosis fungoides International Journal of Dermatology · 1998 · 3 citations
    9. Spiny Hyperkeratotic Projections on the Face and Extremities of a Kidney Transplant Recipient—Quiz Case Archives of dermatology · 2006 · 21 citations
    10. Pruritic Hyperkeratotic Facial Papules Archives of dermatology · 1997 · 1 citations
    11. An Unusual Case of Tinea Capitis Presented as Erythematous, Hyperkeratotic, Scaly Plaque with Alopecia Indian Dermatology Online Journal · 2024
    12. Systematized Epidermal Nevus with Epidermolytic Hyperkeratosis Improving with Topical Calcipotriol/Betametasone Dipropionate Combination Ointment Pediatric Dermatology · 2012 · 12 citations
    13. Intracorneal vacuoles in skin diseases with parakeratotic hyperkeratosis in the dog: a retrospective light‐microscopy study of 111 cases (1973–2000) Veterinary Dermatology · 2002 · 7 citations
    14. Unilateral nevoid hyperkeratosis of the nipple and areola in a Saudi female Our Dermatology Online · 2018 · 2 citations
    15. <i>GJB6</i> missense variant in a Labrador Retriever with paw pad hyperkeratosis Animal Genetics · 2026
    16. Actinic Hyperkeratosis Treated with Retinol Combined with a Polylysine Biovector: A Case Report 2025
    17. Actinic Hyperkeratosis Treated with Retinol Combined with A Polylysine Biovector: A Case Report ARC Journal of Clinical Case Reports · 2025
    18. A Rare Case of Orthokeratotic Hyperkeratosis in a Kid Induced by Malassezial Dermatitis The Indian Veterinary Journal · 2024
    19. Multiple minute digitate hyperkeratosis Journal of the European Academy of Dermatology and Venereology · 2002 · 9 citations
    20. 54269 Patchy hair loss, hyperpigmented plaques, and hyperkeratotic papules in a middle aged woman Journal of the American Academy of Dermatology · 2024
    21. BRAF Inhibitor Dabrafenib in Patients with Metastatic <i>BRAF</i>-Mutant Thyroid Cancer Thyroid · 2014 · 188 citations
    22. A Novel Connexin 26 Mutation in a Patient Diagnosed with Keratitis–Ichthyosis–Deafness Syndrome 2002 · 152 citations
    23. Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice Oncogene · 1997 · 147 citations
    24. Suprabasal Desmoglein 3 Expression in the Epidermis of Transgenic Mice Results in Hyperproliferation and Abnormal Differentiation Molecular and cellular biology · 2002 · 108 citations
    25. Keratin 17 Expression in the Hard Epithelial Context of the Hair and Nail, and its Relevance for the Pachyonychia Congenita Phenotype Journal of Investigative Dermatology · 2000 · 88 citations
    26. Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease Journal of Cell Science · 2008 · 85 citations
    27. Activation of Nrf2 in keratinocytes causes chloracne (MADISH)‐like skin disease in mice EMBO molecular medicine · 2014 · 81 citations
    28. Inherited ichthyoses/generalized Mendelian disorders of cornification European journal of human genetics · 2012 · 81 citations
    29. Clinical Findings, Cutaneous Pathology, and Response to Therapy in 21 Patients With Keratosis Pilaris Atrophicans Archives of dermatology · 1994 · 78 citations
    30. Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function Cell death and disease · 2018 · 74 citations