Sebaceous Gland, Hair Shaft, and Epidermal Barrier Abnormalities in Keratosis Pilaris with and without Filaggrin Deficiency

    Robert Gruber, Jeffrey Sugarman, Debra Crumrine, Melanie Hupe, Theodora M. Mauro, Elizabeth A. Mauldin, Jacob P. Thyssen, Johanna M. Brandner, Hans Christian Hennies, Matthias Schmuth, Peter M. Elias
    TLDR Keratosis pilaris is often linked to genetic mutations and causes skin and hair abnormalities, regardless of those mutations.
    The study investigated keratosis pilaris (KP) in 20 patients and 20 controls, focusing on abnormalities in sebaceous glands, hair shafts, and the epidermal barrier, with and without filaggrin (FLG) deficiency. It found that KP was associated with significant changes in these skin structures, including hyperkeratosis, hypergranulosis, mild T helper cell type 1-dominant inflammation, follicular plugging, absence of sebaceous glands, and hair shaft abnormalities, regardless of FLG status. The absence of sebaceous glands was suggested as an early step in KP pathogenesis, leading to subsequent hair shaft and epithelial barrier abnormalities. The study concluded that while FLG mutations increase the risk of KP, they are not solely responsible for the condition, with environmental and hormonal factors also playing a role.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 17 results

      community My Experience and a Discourse on "DUPA"

      in Treatment  9 upvotes 10 months ago
      The user discusses their hair loss experience, exploring various hypotheses including thyroid levels, vitamin D, DHEA, nutritional deficiency, diabetes, seborrheic dermatitis, lack of nutrition to hair follicles, chronic inflammation, female pattern hair loss causes, cortisol, and prolactin levels. They are currently using finasteride, beta-sitosterol, and have tried topical dutasteride and microneedling therapy.

      community My skin is always dry and flakes like chalk (25)

      in Transgender  6 upvotes 11 months ago
      The user underwent a biopsy two years ago and was diagnosed with keratosis pilaris, leading to hair issues. They tried treatments including Minoxidil, betamethasone, lymecycline, topical Accutane, and dutasteride, as well as diet changes, without improvement in hair thickness or skin dryness.

      community The hardest hair protocol ever!

      in Research/Science  10 upvotes 2 years ago
      The user is using RU58841, finasteride, dutasteride, and minoxidil to slow down aggressive hair loss but is still experiencing hair shedding due to high testosterone levels. They plan to use ostarine to lower testosterone and prevent hair loss while maintaining muscle mass, and will continue using the other treatments.

      community Losing Hair on Dutasteride? You might have LPP

      in Research/Science  96 upvotes 3 weeks ago
      Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.

    Similar Research

    5 / 1000+ results