Preparing the Hair Follicle Canal for Hair Shaft Emergence

    October 2020 in “ Experimental dermatology ”
    Arlee L. Mesler, Rachel E. Benedeck, Sunny Y. Wong
    Studysummary This study reports that during late embryogenesis and early postnatal development, K79-expressing keratinocytes change and die independently of sebaceous glands to form the hair follicle opening, potentially influencing conditions like ingrown hairs or acne.
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    Research cited in this study 19

    1. Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium Cell · 2019
    2. Loss of Gata6 Causes Dilation of the Hair Follicle Canal and Sebaceous Duct Experimental Dermatology · 2018
    3. Skin Cell Heterogeneity in Development, Wound Healing, and Cancer Trends in cell biology · 2018
    4. Wounding Induces Dedifferentiation of Epidermal Gata6+ Cells and Acquisition of Stem Cell Properties Nature cell biology · 2017
    5. Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin Cell host & microbe · 2017
    6. Sebaceous Gland, Hair Shaft, and Epidermal Barrier Abnormalities in Keratosis Pilaris with and without Filaggrin Deficiency ˜The œAmerican journal of pathology · 2015
    7. Deciphering the Functions of the Hair Follicle Infundibulum in Skin Physiology and Disease Cell and Tissue Research · 2014
    8. Keratin 79 Identifies a Novel Population of Migratory Epithelial Cells That Initiates Hair Canal Morphogenesis and Regeneration Development · 2013
    9. A Practical Guide for the Study of Human and Murine Sebaceous Glands In Situ Experimental Dermatology · 2013
    10. Cell Death by Cornification Biochimica et biophysica acta. Molecular cell research · 2013
    11. Development and Homeostasis of the Sebaceous Gland Seminars in Cell & Developmental Biology · 2012
    12. Pattern of Tissue Invasion by Propionibacterium Acnes in Acne Vulgaris Journal of dermatological science · 2012
    13. Matrix Metalloproteinase-9 Is Involved in the Regulation of Hair Canal Formation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2010
    14. Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin Nature Reviews Molecular Cell Biology · 2009
    15. Mice Expressing a Mutant KRT75 (K6hf) Allele Develop Hair and Nail Defects Resembling Pachyonychia Congenita Journal of Investigative Dermatology · 2007
    16. An Unusual Ala12Thr Polymorphism in the 1A Alpha-Helical Segment of the Companion Layer-Specific Keratin K6hf: Evidence for a Risk Factor in the Etiology of the Common Hair Disorder Pseudofolliculitis Barbae Journal of Investigative Dermatology · 2004
    17. Matriptase/MT-SP1 Is Required for Postnatal Survival, Epidermal Barrier Function, Hair Follicle Development, and Thymic Homeostasis Oncogene · 2002
    18. The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling ˜The œAmerican journal of pathology · 2002
    19. Asebia-2J (Scd1ab2J): A New Allele and a Model for Scarring Alopecia ˜The œAmerican journal of pathology · 2000

    Related research 9

    1. Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes Journal of St. Marianna University · 2022
    2. Effect of Intense Pulsed Light Treatment on Human Skin In Vitro: Analysis of Immediate Effects on Dermal Papillae and Hair Follicle Stem Cells British Journal of Dermatology · 2013
    3. Clinical Effect of Human Dermal Papilla Cells Conditioned Medium on Female Androgenetic Alopecia Medical Journal of National Defending Forces in Northwest China · 2011
    4. Intermediate Hair Follicles: A New, More Clinically Relevant Model for Hair Growth Investigations British Journal of Dermatology · 2010
    5. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    6. Clinical Observed Human Dermal Papilla Cells Conditioned Medium Treated Androgenetic Alopecia Chinese Journal of Aesthetic Medicine · 2009
    7. Study on Hair Follicle Formation Induced by Dermal Papilla Cells Chinese Journal of Reparative and Reconstructive Surgery · 2003
    8. Trans-Species Hair Growth Induction by Human Hair Follicle Dermal Papillae Experimental Dermatology · 2001
    9. Role of Hair Papilla Cells in Induction and Regeneration Processes of Hair Follicles Wound Repair and Regeneration · 1998