Pattern of Tissue Invasion by Propionibacterium Acnes in Acne Vulgaris

March 2012 in “ Journal of dermatological science ”

Oleg A. Alexeyev, Bertil Lundskog, Rūta Gancevičienė, Ruth H. Palmer, Andrew McDowell, Sheila Patrick, Christos Zouboulis, Irina Golovleva

Propionibacterium acnes acne vulgaris fluorescent in situ hybridization immunofluorescent microscopy immunohistochemistry histochemistry inflammatory cells skin micro-environments P. acnes acne FISH IFM IHC

TLDR The document concludes that advanced methods show the presence of P. acnes in acne lesions but do not prove it causes acne.

The study investigated the presence and localization of Propionibacterium acnes (P. acnes) in acne lesions using advanced visualization techniques such as fluorescent in situ hybridization (FISH), immunofluorescent microscopy (IFM), immunohistochemistry (IHC), and routine histochemistry assays. The goal was to directly detect and co-localize P. acnes with inflammatory cells in acne lesions, addressing the limitations of previous culture-based studies. The findings aimed to provide more precise evidence of P. acnes involvement in acne by identifying its specific sites of colonization within the skin micro-environments.

View this study on jdsjournal.com →

Discuss this study in the Community →

Related Community Posts Join

3 / 3 results

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 65 upvotes 1 year ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community Interesting article links major MPB theories to western diet (and life-style)

in Research/Science 57 upvotes 1 month ago

Poor diet and lifestyle contribute to male pattern baldness. Treatments like Minoxidil, dietary changes, and lifestyle adjustments may help slow hair loss.

Similar Research

5 / 539 results

research Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin

192 citations, March 2017 in “Cell host & microbe”

Hair follicle development and microbes help regulatory T cells gather in newborn skin.

research Index

November 2019 in “Harper's Textbook of Pediatric Dermatology”

The document is a detailed medical reference on skin and genetic disorders.

research Host-Microbiome Interactions and Recent Progress in Understanding the Biology of Acne Vulgaris

194 citations, October 2018 in “Microbiome”

Acne is linked to complex skin microbe interactions, and new findings suggest microbiome-based treatments could be effective.

research Hyaluronic Acid-FGF2-Derived Peptide Bioconjugates for Suppression of FGFR2 and AR Simultaneously as an Acne Antagonist

6 citations, February 2023 in “Journal of nanobiotechnology”

The new anti-acne treatment HA-P5 effectively reduces acne by targeting two key receptors and avoids an enzyme that can hinder treatment.

research Hot Topics in Pediatric Dermatology

1 citations, June 2010 in “Expert Review of Dermatology”

Covers common skin issues in kids, their diagnosis, treatment, and need for specialist care.