Pattern of Tissue Invasion by Propionibacterium Acnes in Acne Vulgaris

March 2012 in “ Journal of dermatological science ”

Oleg A. Alexeyev, Bertil Lundskog, Rūta Gancevičienė, Ruth H. Palmer, Andrew McDowell, Sheila Patrick, Christos Zouboulis, Irina Golovleva

Propionibacterium acnes acne vulgaris fluorescent in situ hybridization immunofluorescent microscopy immunohistochemistry histochemistry inflammatory cells skin micro-environments P. acnes acne FISH IFM IHC

TLDR The document concludes that advanced methods show the presence of P. acnes in acne lesions but do not prove it causes acne.

The study investigated the presence and localization of Propionibacterium acnes (P. acnes) in acne lesions using advanced visualization techniques such as fluorescent in situ hybridization (FISH), immunofluorescent microscopy (IFM), immunohistochemistry (IHC), and routine histochemistry assays. The goal was to directly detect and co-localize P. acnes with inflammatory cells in acne lesions, addressing the limitations of previous culture-based studies. The findings aimed to provide more precise evidence of P. acnes involvement in acne by identifying its specific sites of colonization within the skin micro-environments.

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