Hyaluronic Acid-FGF2-Derived Peptide Bioconjugates for Suppression of FGFR2 and AR Simultaneously as an Acne Antagonist

February 2023 in “ Journal of nanobiotechnology ”

Zijian Su, Hongjie Zhang, Jieqiong Cao, Yuanmeng Sun, Yuling Cai, Bihui Zhang, He Liu, Zilei Zhang, Jianwen Xie, Qilin Meng, Lin Luo, Fu Li, Jingsheng Li, Jin‐Ting Zhang, Xiaojia Chen, Hongyu An

hyaluronic acid FGF2 peptide HA-P5 FGFR2 AR acne sebum SZ95 cells AKR1C3 FGFR inhibitor AZD4547 HA fibroblast growth factor 2 androgen receptor acne lesions sebaceous glands

Studysummary In this study, HA-P5, a nanoparticle derived from peptide and polysaccharide conjugation, effectively reduced acne lesions and sebum production by inhibiting specific receptors in cells, without triggering unfavorable reactions compared to a commercial inhibitor, highlighting HA-P5's potential as a novel acne treatment.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study evaluates the effectiveness of HA-P5, a bioconjugate nanoparticle derived from hyaluronic acid and an FGF2 peptide, in treating acne by inhibiting FGFR2 and AR signaling pathways. HA-P5 significantly reduced acne lesions and sebum accumulation in SZ95 cells and rabbit models without inducing the overexpression of AKR1C3, unlike the commercial FGFR inhibitor AZD4547. The findings suggest that HA-P5 is a promising and safer alternative for acne treatment due to its dual inhibition mechanism and minimal side effects.

View this study on jnanobiotechnology.biomedcentral.com →

Discuss this study in the Community →

Research cited in this study

12 / 12 results

research Topical Antiandrogen Therapies for Androgenetic Alopecia and Acne Vulgaris

7 citations , December 2019 in “American Journal of Clinical Dermatology”

This review discusses the potential efficacy of topical antiandrogen therapies for treating androgenetic alopecia and acne vulgaris, finding promising results but highlighting the need for more comprehensive studies.

research Homeostasis of the Sebaceous Gland and Mechanisms of Acne Pathogenesis

82 citations , May 2019 in “British Journal of Dermatology”

This review discusses various hormones and signaling pathways involved in sebaceous gland homeostasis and their potential impact on acne pathogenesis, but it reports no new experimental findings.

Androgens Modulate Keratinocyte Differentiation Indirectly Through Enhancing Growth Factor Production From Dermal Fibroblasts

research Androgens Modulate Keratinocyte Differentiation Indirectly Through Enhancing Growth Factor Production From Dermal Fibroblasts

20 citations , January 2019 in “Journal of dermatological science”

This study suggests that androgens enhance growth factor production in dermal fibroblasts, which in turn may alter keratinocyte differentiation and contribute to acne lesion formation.

Physicochemical Properties of pH-Sensitive Hydrogels Based on Hydroxyethyl Cellulose–Hyaluronic Acid for Transdermal Delivery Systems for Skin Lesions

research Physicochemical Properties of pH-Sensitive Hydrogels Based on Hydroxyethyl Cellulose–Hyaluronic Acid for Transdermal Delivery Systems for Skin Lesions

118 citations , May 2015 in “European journal of pharmaceutics and biopharmaceutics”

This study found that the pH-sensitive hydrogel HECHA13, containing isoliquiritigenin, effectively inhibited the growth of Propionibacterium acnes and showed promise for transdermal delivery in acne treatment.

research Self-Assembled Polymeric Nanocarriers for the Targeted Delivery of Retinoic Acid to the Hair Follicle

59 citations , January 2015 in “Nanoscale”

In this study, polymeric micelles containing retinoic acid were found to improve targeted delivery to hair follicle structures in human skin more efficiently than a marketed retinoic acid gel, suggesting potentially safer and more effective acne treatment.

research C-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis

60 citations , February 2013 in “Cell reports”

This study demonstrates that c-MYC overexpression in sebaceous glands affects differentiation via a regulatory axis involving the androgen receptor and p53, influencing carcinoma formation outcomes.

research Role of Insulin, Insulin-Like Growth Factor-1, Hyperglycemic Food, and Milk Consumption in the Pathogenesis of Acne Vulgaris

200 citations , August 2009 in “Experimental dermatology”

This article reviews the role of IGF-1 in acne pathogenesis and discusses how diet and smoking may influence insulin/IGF-1 signaling, but reports no new clinical results.

research Role of FGFR2-Signaling in the Pathogenesis of Acne

63 citations , May 2009 in “Dermato-endocrinology”

This review explores the role of FGFR2b-signaling in the pathogenesis of acne, highlighting its influence on sebaceous gland physiology and the effects of anti-acne agents like isotretinoin.

research Anti-Acne Agents Attenuate FGFR2 Signal Transduction in Acne

65 citations , February 2009 in “The journal of investigative dermatology/Journal of investigative dermatology”

This paper discusses the hypothesis that anti-acne agents may work by reducing FGFR2 signaling, and emphasizes FGFR2's potential role in acne pathogenesis, but it reports no new experimental findings.

research Hormonal Therapy for Acne

96 citations , September 2008 in “Seminars in Cutaneous Medicine and Surgery”

This review discusses the hormonal influences on acne's development in women and the therapeutic potential of hormonal treatments, but it reports no new clinical results.

research Acne and Sebaceous Gland Function

463 citations , September 2004 in “Clinics in dermatology”

This review discusses the development, function, and complex roles of sebaceous glands in acne and suggests future acne treatments should target inflammation and lipid production; it reports no new clinical results.

research Keratinocyte Growth Factor Is an Important Endogenous Mediator of Hair Follicle Growth, Development, and Differentiation. Normalization of the Nu/Nu Follicular Differentiation Defect and Amelioration of Chemotherapy-Induced Alopecia.

219 citations , July 1995 in “PubMed”

This study found that recombinant keratinocyte growth factor (rKGF) stimulated hair growth and provided a protective effect against alopecia in murine models, suggesting its role in hair follicle development and regeneration.