Hyaluronic Acid-FGF2-Derived Peptide Bioconjugates for Suppression of FGFR2 and AR Simultaneously as an Acne Antagonist

    February 2023 in “ Journal of nanobiotechnology ”
    Zijian Su, Hongjie Zhang, Jieqiong Cao, Yuanmeng Sun, Yuling Cai, Bihui Zhang, He Liu, Zilei Zhang, Jianwen Xie, Qilin Meng, Lin Luo, Fu Li, Jingsheng Li, Jin‐Ting Zhang, Xiaojia Chen, Hongyu An
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    TLDR The new anti-acne treatment HA-P5 effectively reduces acne by targeting two key receptors and avoids an enzyme that can hinder treatment.
    The study evaluates the effectiveness of HA-P5, a bioconjugate nanoparticle derived from hyaluronic acid and an FGF2 peptide, in treating acne by inhibiting FGFR2 and AR signaling pathways. HA-P5 significantly reduced acne lesions and sebum accumulation in SZ95 cells and rabbit models without inducing the overexpression of AKR1C3, unlike the commercial FGFR inhibitor AZD4547. The findings suggest that HA-P5 is a promising and safer alternative for acne treatment due to its dual inhibition mechanism and minimal side effects.
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