Hyaluronic Acid-FGF2-Derived Peptide Bioconjugates for Suppression of FGFR2 and AR Simultaneously as an Acne Antagonist

    February 2023 in “ Journal of nanobiotechnology ”
    Zijian Su, Hongjie Zhang, Jieqiong Cao … Hongyu An
    Studysummary In this study, HA-P5, a nanoparticle derived from peptide and polysaccharide conjugation, effectively reduced acne lesions and sebum production by inhibiting specific receptors in cells, without triggering unfavorable reactions compared to a commercial inhibitor, highlighting HA-P5's potential as a novel acne treatment.
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    Research cited in this study 12

    1. Topical Antiandrogen Therapies for Androgenetic Alopecia and Acne Vulgaris American Journal of Clinical Dermatology · 2019
    2. Homeostasis of the Sebaceous Gland and Mechanisms of Acne Pathogenesis British Journal of Dermatology · 2019
    3. Androgens Modulate Keratinocyte Differentiation Indirectly Through Enhancing Growth Factor Production From Dermal Fibroblasts Journal of dermatological science · 2019
    4. Physicochemical Properties of pH-Sensitive Hydrogels Based on Hydroxyethyl Cellulose–Hyaluronic Acid for Transdermal Delivery Systems for Skin Lesions European journal of pharmaceutics and biopharmaceutics · 2015
    5. Self-Assembled Polymeric Nanocarriers for the Targeted Delivery of Retinoic Acid to the Hair Follicle Nanoscale · 2015
    6. C-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis Cell reports · 2013
    7. Role of Insulin, Insulin-Like Growth Factor-1, Hyperglycemic Food, and Milk Consumption in the Pathogenesis of Acne Vulgaris Experimental dermatology · 2009
    8. Role of FGFR2-Signaling in the Pathogenesis of Acne Dermato-endocrinology · 2009
    9. Anti-Acne Agents Attenuate FGFR2 Signal Transduction in Acne ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2009
    10. Hormonal Therapy for Acne Seminars in Cutaneous Medicine and Surgery · 2008
    11. Acne and Sebaceous Gland Function Clinics in dermatology · 2004
    12. Keratinocyte Growth Factor Is an Important Endogenous Mediator of Hair Follicle Growth, Development, and Differentiation. Normalization of the Nu/Nu Follicular Differentiation Defect and Amelioration of Chemotherapy-Induced Alopecia. PubMed · 1995