Search

for
Search:

GlossaryAldo-Keto Reductase Family 1 Member C3 (AKR1C3)

enzyme involved in hormone metabolism affecting hair growth and alopecia

Aldo-Keto Reductase Family 1 Member C3 (AKR1C3) is an enzyme that plays a crucial role in the metabolism of steroids, prostaglandins, and other compounds. It is involved in the conversion of hormones like testosterone and estrogen, which can influence various physiological processes, including hair growth and the development of conditions like alopecia.

Related Terms

Learn

0 / 0 results

— no results

Research

5 / 118 results

Overexpression of Aldo-Keto Reductase 1C3 in LNCaP Cells Diverts Androgen Metabolism Towards Testosterone Resulting in Resistance to the 5α-Reductase Inhibitor Finasteride

research Overexpression of Aldo-Keto Reductase 1C3 in LNCaP Cells Diverts Androgen Metabolism Towards Testosterone Resulting in Resistance to the 5α-Reductase Inhibitor Finasteride

45 citations , January 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

research Aldo-Keto Reductase (AKR) 1C3 Inhibitors: A Patent Review

70 citations , September 2017 in “Expert opinion on therapeutic patents”

The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

research A New Target for Squamous Cell Skin Cancer?

6 citations , October 2014 in “Experimental Dermatology”

Prostaglandins and the enzyme AKR1C3 could play a role in skin cancer and hair loss, and further research is needed to understand these mechanisms.

research Unraveling the Link Between Insulin Resistance and Androgen Excess

December 2015 in “University of Birmingham Institutional Research Archive (University of Birmingham)”

AKR1C3 could be a treatment target for metabolic issues in PCOS.

research Hyaluronic Acid-FGF2-Derived Peptide Bioconjugates for Suppression of FGFR2 and AR Simultaneously as an Acne Antagonist

6 citations , February 2023 in “Journal of nanobiotechnology”

The new anti-acne treatment HA-P5 effectively reduces acne by targeting two key receptors and avoids an enzyme that can hinder treatment.

View more "akr1c3" in research →

Community Join

5 / 6 results

community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

in Update 34 upvotes 6 years ago

The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.

community Bile Acid-Mediated DHT Dysregulation Hypothesis

in Research/Science 13 upvotes 1 year ago

Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

community Switched from finasteride to dutasteride - 2 month update

in Finasteride/Dutasteride 6 upvotes 2 years ago

The user switched from finasteride to dutasteride for hair loss treatment, but experienced increased libido, itchy scalp, and accelerated hair loss. Another user suggested that genetic variations might cause dutasteride to be less effective and recommended checking for specific genetic markers.

community The theory that explains everything - First Evidence of Hair regrow attributed to upregulating 3aHSD

in Treatment 174 upvotes 4 years ago

Hair regrowth treatment involving 3aHSD enzyme shows 6% improvement in 18 weeks. Sulforaphane, L-Menthol, and Dexpanthenol are potential ingredients for new hair loss solution.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 446 upvotes 4 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

View more "akr1c3" in community →