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The Evolution of Healthy Skin to Acne Lesions: A Longitudinal, In Vivo Evaluation with Reflectance Confocal Microscopy and Optical Coherence Tomography

research The evolution of healthy skin to acne lesions: a longitudinal, in vivo evaluation with reflectance confocal microscopy and optical coherence tomography

19 citations , April 2019 in “Journal of the European Academy of Dermatology and Venereology”

This study found that acne lesion formation involves early hyperkeratinization and inflammation around hair follicles, creating a self-sustaining cycle that may progressively worsen acne.

research Acne inversa-like lesions associated with the multi-kinase inhibitor sorafenib

11 citations , December 2013 in “Clinical and Experimental Dermatology”

This article reviews the use of sorafenib, a multikinase inhibitor, for treating certain carcinomas, noting that cutaneous toxicity during treatment may indicate successful antitumor activity; however, it reports no new clinical results.

research Immunolocalization of 5α-Reductase Isozymes in Acne Lesions and Normal Skin

45 citations , September 2000 in “Archives of dermatology”

This study found that 5alpha-reductase type 1 localizes specifically to sebaceous glands in both normal and acne follicles, suggesting its role in sebum regulation.

research No evidence for follicular keratinocyte hyperproliferation in acne lesions as compared to autologous healthy hair follicles

7 citations , March 2018 in “Experimental Dermatology”

This study found no evidence of increased keratinocyte proliferation in acne vulgaris, suggesting that other mechanisms may be responsible for hyperkeratinization in acne pathogenesis.

research 1318 Both lesional and non-lesional skin from acne patients shows robust IL-17-skewing and upregulation of antimicrobial peptides

April 2018 in “Journal of Investigative Dermatology”

This study found that acne lesions and nonlesional skin in mild-to-moderate acne patients showed significant Th17-skewing and increased antimicrobials, suggesting systemic targets like IL-17/IL-23/IL-36 could be therapeutic.

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community I shaved my head. Trust the progress guys

in Shaved/buzzed 460 upvotes 1 year ago

The user shaved their head and is using finasteride and minoxidil for hair loss, expressing confidence in the process despite challenges. They are considering additional treatments like microneedling and are open to trying different looks, including facial hair growth.

community My 5 year hair loss journey on Min & Fin.

1220 upvotes 5 months ago

A user shared their 5-year experience using minoxidil and finasteride, noting significant hair improvements without side effects. Consistency, a positive mindset, and lifestyle changes like a healthier diet and better sleep were key to their success.

community Boyfriend’s hair transformation in 10 months 🥲

in Progress Pictures 2281 upvotes 1 year ago

A boyfriend's hair improved significantly over 10 months using minoxidil, steroid cream, antihistamine cream, and wild growth oil, with a strict cleaning regimen. His partner's dedicated care contributed to the transformation.

community Could microneedling for the next 5 years cause any permanent damage?

in Microneedling 22 upvotes 3 years ago

Microneedling for hair loss and its potential long-term effects. Some users believe it can cause fibrosis and scar tissue if done too frequently or deeply, while others claim it has improved their hair loss when done correctly. There is limited scientific research on the topic.

community I messed up. Regrew my hair and then lost it all.

495 upvotes 1 year ago

Stopping hair loss treatments like finasteride and minoxidil can result in losing regrown hair, highlighting the importance of consistent use. Restarting these treatments may cause temporary shedding, but hair can regrow with continued use.

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