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    C-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis

    February 2013 in “ Cell reports ”
    Denny L. Cottle, Kai Kretzschmar, Pawel J. Schweiger … Fiona M. Watt
    Studysummary This study demonstrates that c-MYC overexpression in sebaceous glands affects differentiation via a regulatory axis involving the androgen receptor and p53, influencing carcinoma formation outcomes.
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    Research cited in this study 8

    1. Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences Between Sox2-Positive and Sox2-Negative Cells In Vitro and In Vivo Journal of Investigative Dermatology · 2011
    2. TCF/Lef1 Activity Controls Establishment of Diverse Stem and Progenitor Cell Compartments in Mouse Epidermis The EMBO Journal · 2011
    3. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    4. Higher Levels of Steroidogenic Acute Regulatory Protein and Type I 3β-Hydroxysteroid Dehydrogenase in the Scalp of Men with Androgenetic Alopecia Journal of Investigative Dermatology · 2006
    5. Loss of Keratin 10 Is Accompanied by Increased Sebocyte Proliferation and Differentiation European journal of cell biology · 2004
    6. C-Myc Activation in Transgenic Mouse Epidermis Results in Mobilization of Stem Cells and Differentiation of Their Progeny Current Biology · 2001
    7. Asebia-2J (Scd1ab2J): A New Allele and a Model for Scarring Alopecia ˜The œAmerican journal of pathology · 2000
    8. The Human Sebocyte Culture Model Provides New Insights Into Development and Management of Seborrhoea and Acne Dermatology · 1998