BLIMP1 Is Required for Postnatal Epidermal Homeostasis but Does Not Define a Sebaceous Gland Progenitor Under Steady-State Conditions

September 2014 in “ Stem cell reports ”

Kai Kretzschmar, Denny L. Cottle, Giacomo Donati, Ming-Feng Chiang, Sven R Quist, Harald Gollnick, Ken Natsuga, Kuo‐I Lin, Fiona M. Watt

BLIMP1 epidermis sebaceous gland hair follicle c-Myc androgen signaling differentiation defects sebocytes lineage-tracing homeostasis skin oil gland hair root Myc hormone signaling cell differentiation oil-producing cells cell tracking balance

Studysummary In this study, BLIMP1 was found to function in terminally differentiated epidermal cells to maintain homeostasis, rather than defining a sebocyte progenitor population.

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