Search

for
Search:

Research

5 / 1000+ results

research Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation

195 citations , November 2001 in “The Journal of Cell Biology”

This study found that desmocollin 1 is crucial for strong adhesion and barrier maintenance in the mouse epidermis, with its absence leading to skin and hair issues resembling chronic dermatitis.

research Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia.

219 citations , July 1995 in “PubMed”

This study found that recombinant keratinocyte growth factor (rKGF) stimulated hair growth and provided a protective effect against alopecia in murine models, suggesting its role in hair follicle development and regeneration.

research Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal Differentiation, and IL-36 Signature

15 citations , June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study identifies KLK14 as a significant factor contributing to hair defects and skin inflammation in a mouse model of Netherton syndrome.

research Genetic Defects of Female Sexual Differentiation

November 2016 in “Elsevier eBooks”

This chapter reviews genetic defects in female sexual differentiation, focusing on 46,XX disorders of sex development and the impact of genetic factors and sex steroids on development, but reports no new clinical findings.

research `Cyclic alopecia' inMsx2mutants: defects in hair cycling and hair shaft differentiation

158 citations , December 2002 in “Development”

In this study, Msx2-deficient mice showed progressive hair loss due to shortened anagen phase and prolonged catagen and telogen phases, resulting in cyclic alopecia with structurally abnormal hair shafts.

View more "differentiation defects" in research →

Community Join

5 / 43 results

community New Hair Loss Cure: AMP-303 Is Back. It’s what PP405 should have been.

7 upvotes 5 months ago

AMP-303 and AMP-601 are new hair loss treatments targeting dermal papilla cells, with AMP-303 showing early efficacy in transitioning vellus hairs to terminal hairs after one injection. Further clinical trials are planned, and these treatments are seen as promising due to their biologic approach and less frequent application compared to daily treatments.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community Stopped taking 1mg Fin September 2024 - 3 months later….

in Progress Pictures 799 upvotes 1 year ago

The user stopped finasteride for three months to try for a baby but continued using minoxidil and micro-needling. They are concerned about hair shedding and plan to resume finasteride after the baby is born.

community The Real Cause Of Androgenetic Alopecia

675 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community A Nuanced Look at Microdosing Topical Finasteride

86 upvotes 2 years ago

The conversation discusses using a low dose of topical finasteride to achieve hair benefits with minimal systemic exposure. Users share experiences and opinions on dosing, systemic buildup, and side effects of both topical and oral finasteride.

View more "differentiation defects" in community →

Learn

2 / 801 results

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Stem Cell Factor

View more "differentiation defects" in learn →

Experts

— no results

Try a deeper search in experts →

Clinics

— no results

Try a deeper search in clinics →