C/EBPα and C/EBPβ Are Required for Sebocyte Differentiation and Stratified Squamous Differentiation in Adult Mouse Skin

    March 2010 in “ PloS one ”
    John S. House, Shuyu Zhu, Rakesh Ranjan, Keith E. Linder, Robert C. Smart
    TLDR C/EBPalpha and C/EBPbeta are crucial for normal skin and oil gland cell development in adult mice.
    The study concluded that the transcription factors C/EBPα and C/EBPβ were essential for sebocyte differentiation and stratified squamous differentiation in adult mouse skin. The absence of these factors led to significant defects in sebaceous gland function and epidermal differentiation, including hyperproliferation of keratinocytes and severe morphological defects in sebaceous glands. The findings highlighted the critical, redundant roles of C/EBPα and C/EBPβ in maintaining skin homeostasis and provided insights into the molecular mechanisms underlying skin differentiation processes.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 400 results

      community C’est terrible - at my wits end

      in Female  443 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community Vitamin C and hair growth PH levels

      in Product  34 upvotes 2 years ago
      The conversation is about using vitamin C and Magnesium L-Threonate for hair growth by reducing DHT binding to dermal papilla cells. The original post about vitamin C's pH levels and sebum control was possibly removed by a moderator.

      community Vitamin c serum after dermarolling.

      in Treatment  3 upvotes 6 years ago
      Using Vitamin C serum after dermarolling may help with healing and hair health. The safety of additional ingredients like Glycerin, Propylene Glycol, Phenoxyethanol, Sodium Benzoate, and Sodium Metabisulfite in hair regrowth is questioned.

      community the post about vitamin c and pH levels is legit.

      in Update  13 upvotes 2 years ago
      Using vitamin C in shampoo to adjust pH levels can improve hair health and reduce oiliness and dandruff. The user mixed vitamin C powder with conditioner, achieving positive results.

    Related Research

    1 / 1 results