C/EBPα and C/EBPβ Are Required for Sebocyte Differentiation and Stratified Squamous Differentiation in Adult Mouse Skin

    March 2010 in “ PloS one ”
    John S. House, Shuyu Zhu, Rakesh Ranjan, Keith E. Linder, Robert C. Smart
    TLDR C/EBPalpha and C/EBPbeta are crucial for normal skin and oil gland cell development in adult mice.
    The study concluded that the transcription factors C/EBPα and C/EBPβ were essential for sebocyte differentiation and stratified squamous differentiation in adult mouse skin. The absence of these factors led to significant defects in sebaceous gland function and epidermal differentiation, including hyperproliferation of keratinocytes and severe morphological defects in sebaceous glands. The findings highlighted the critical, redundant roles of C/EBPα and C/EBPβ in maintaining skin homeostasis and provided insights into the molecular mechanisms underlying skin differentiation processes.
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