Aging in the Sebaceous Gland

The document reviewed the aging process of sebaceous glands (SGs), noting that aging led to changes in sebum production and composition, with peaks at 40 years for females and 50 years for males. It highlighted that intrinsic factors like genetic variations and extrinsic factors such as UV exposure and pollution contributed to SG aging by generating reactive oxygen species and affecting molecular pathways like Wnt/β-catenin. These changes resulted in reduced lipid secretion and gland hyperplasia. The review identified key molecular pathways, including TGF-β, p53, and Notch, as influential in SG aging. It also discussed management strategies like antioxidants and hormone replacement therapy but emphasized the need for further research to understand the molecular mechanisms and sebum composition changes across different ages.