Particulate Matter 2.5 Damages Skin Cells by Inducing Oxidative Stress, Subcellular Organelle Dysfunction, and Apoptosis

    March 2018 in “ Archives of Toxicology ”
    Mei Jing Piao, Meejung Ahn, Kyoung Ah Kang, Yea Seong Ryu, Yu Jae Hyun, Kristina Shilnikova, Ao Xuan Zhen, Jin Woo Jeong, Yung Hyun Choi, Hee Kyoung Kang, Young Sang Koh, Jin Won Hyun
    Image of study
    TLDR Tiny pollution particles called PM2.5 can harm skin cells by causing stress, damage to cell parts, and cell death.
    The document from March 26, 2018, details a study that investigated the harmful effects of particulate matter 2.5 (PM2.5) on skin cells, including human HaCaT keratinocytes and mouse skin. The study found that exposure to PM2.5 caused oxidative stress, leading to DNA damage, lipid peroxidation, and protein carbonylation. This oxidative stress resulted in endoplasmic reticulum stress, mitochondrial swelling, autophagy, and apoptosis in the skin cells. The study also demonstrated that the antioxidant N-acetyl cysteine could mitigate the damage caused by PM2.5, confirming that the cellular toxicity was due to oxidative stress. However, the specific number of participants or samples used in the study was not provided in the summary.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 635 results

      community People here just don't know what they are letting themselves in for!

      in Chat  122 upvotes 2 years ago
      The conversation discusses hair loss treatments, emphasizing the importance of patience and sticking with a treatment for at least 12-18 months before judging its effectiveness or adding new treatments. Users share experiences and agree that introducing treatments too quickly can lead to panic and negative outcomes.

      community 2 months of Oral .5 Fin 2.5 Min - Let me know your thoughts!

      in Is this regrowth?  160 upvotes 1 year ago
      The user is experiencing positive hair regrowth after two months of using oral finasteride (0.5 mg) and minoxidil (2.5 mg) and is considering a hair transplant. They are seeking advice on surgeons closer to the U.S. and discussing potential side effects and alternative treatments.

      community Why I deleted my YouTube channel Part I

      in Update  118 upvotes 4 years ago
      A YouTuber named Kevin, also known as Rider_Of_Roach, who deleted his YouTube channel due to personal attacks and controversy surrounding his views on hair loss treatments. He advocated for FDA-approved treatments like finasteride and minoxidil but faced backlash from those who disagreed with him. The conversation also discusses his past trolling behavior and a lawsuit he filed against a website that published false information about him. Despite some disagreements, many viewers appreciated his research-based content and hope to see him return in the future.

      community 9 months oral min, 2 months topical min. Late 30s.

      in Progress Pictures  54 upvotes 1 year ago
      The user used oral finasteride, topical minoxidil foam, a derma roller, keto shampoo, Hims thick fix shampoo, hair dye, and rosemary oil for hair restoration. They reported no side effects and noted significant improvement, especially in the hairline.

      community Why does it seem everyone favors finasteride over dutasteride?

      in Female  62 upvotes 1 year ago
      The conversation discusses preferences for hair loss treatments, specifically finasteride over dutasteride. Users share personal experiences, cost considerations, FDA approval status, and potential side effects, with some switching between treatments to find what works best for them.

    Similar Research

    5 / 1000+ results