Particulate Matter 2.5 Damages Skin Cells by Inducing Oxidative Stress, Subcellular Organelle Dysfunction, and Apoptosis

    March 2018 in “ Archives of Toxicology ”
    Mei Jing Piao, Meejung Ahn, Kyoung Ah Kang, Yea Seong Ryu, Yu Jae Hyun, Kristina Shilnikova, Ao Xuan Zhen, Jin Woo Jeong, Yung Hyun Choi, Hee Kyoung Kang, Young Sang Koh, Jin Won Hyun
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    TLDR Tiny pollution particles called PM2.5 can harm skin cells by causing stress, damage to cell parts, and cell death.
    The document from March 26, 2018, details a study that investigated the harmful effects of particulate matter 2.5 (PM2.5) on skin cells, including human HaCaT keratinocytes and mouse skin. The study found that exposure to PM2.5 caused oxidative stress, leading to DNA damage, lipid peroxidation, and protein carbonylation. This oxidative stress resulted in endoplasmic reticulum stress, mitochondrial swelling, autophagy, and apoptosis in the skin cells. The study also demonstrated that the antioxidant N-acetyl cysteine could mitigate the damage caused by PM2.5, confirming that the cellular toxicity was due to oxidative stress. However, the specific number of participants or samples used in the study was not provided in the summary.
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