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GlossaryEndoplasmic Reticulum Stress

cellular condition where protein folding machinery becomes overwhelmed

Endoplasmic Reticulum Stress (ER Stress) occurs when the endoplasmic reticulum, a cellular organelle responsible for protein folding and processing, becomes overwhelmed or dysfunctional. This can lead to the accumulation of misfolded or unfolded proteins, triggering a cellular response known as the Unfolded Protein Response (UPR) to restore normal function. If unresolved, ER stress can contribute to various diseases, including neurodegenerative disorders and diabetes.

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research Endoplasmic Reticulum Stress at the Crossroads of Progeria and Atherosclerosis

11 citations, March 2019 in “EMBO molecular medicine”

A defective protein in progeria causes cell death and atherosclerosis, but a treatment targeting cell stress may reduce these effects.

Probiotic-Functionalized Silk Fibroin/Sodium Alginate Scaffolds With Endoplasmic Reticulum Stress-Relieving Properties For Promoted Scarless Wound Healing

research Probiotic-Functionalized Silk Fibroin/Sodium Alginate Scaffolds With Endoplasmic Reticulum Stress-Relieving Properties For Promoted Scarless Wound Healing

7 citations, January 2023 in “ACS Applied Materials & Interfaces”

Probiotic-coated silk/alginate scaffolds help heal wounds faster and with less scarring.

Melatonin Protects Cochlear Hair Cells from Nicotine-Induced Injury Through Inhibiting Apoptosis, Inflammation, Oxidative Stress, and Endoplasmic Reticulum Stress

research Melatonin Protects Cochlear Hair Cells from Nicotine-Induced Injury Through Inhibiting Apoptosis, Inflammation, Oxidative Stress, and Endoplasmic Reticulum Stress

5 citations, July 2021 in “Basic & Clinical Pharmacology & Toxicology”

Melatonin may protect ear cells from damage caused by nicotine.

research Role of Epigallocatechin-3-Gallate from Green Tea in Iron Chelation and Endoplasmic Reticulum Stress Pathway in Colorectal Cancer Cells

December 2018

Green tea compound EGCG could potentially treat colorectal cancer by removing iron and causing stress in cancer cells leading to their death.

research Endoplasmic Reticulum Stress Upregulates NKG2D Ligands in the Hair Follicle

April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

Stress in hair follicle cells increases certain immune-related proteins, which might contribute to hair loss conditions.

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