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    Glossary Endoplasmic Reticulum Stress

    cellular condition where protein folding machinery becomes overwhelmed

    Endoplasmic Reticulum Stress (ER Stress) occurs when the endoplasmic reticulum, a cellular organelle responsible for protein folding and processing, becomes overwhelmed or dysfunctional. This can lead to the accumulation of misfolded or unfolded proteins, triggering a cellular response known as the Unfolded Protein Response (UPR) to restore normal function. If unresolved, ER stress can contribute to various diseases, including neurodegenerative disorders and diabetes.

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    Research 30 of 870

    1. Endoplasmic reticulum stress at the crossroads of progeria and atherosclerosis EMBO molecular medicine · 2019 · 11 citations
    2. Probiotic-Functionalized Silk Fibroin/Sodium Alginate Scaffolds with Endoplasmic Reticulum Stress-Relieving Properties for Promoted Scarless Wound Healing ACS Applied Materials & Interfaces · 2023 · 7 citations
    3. Melatonin protects cochlear hair cells from nicotine‐induced injury through inhibiting apoptosis, inflammation, oxidative stress and endoplasmic reticulum stress Basic & Clinical Pharmacology & Toxicology · 2021 · 5 citations
    4. A novel <i>MBTPS2</i> variant associated with BRESHECK syndrome impairs sterol‐regulated transcription and the endoplasmic reticulum stress response American Journal of Medical Genetics Part A · 2021 · 5 citations
    5. Role of epigallocatechin-3-gallate from green tea in iron chelation and endoplasmic reticulum stress pathway in colorectal cancer cells 2018
    6. 616 Endoplasmic reticulum stress upregulates NKG2D ligands in the hair follicle 2017
    7. The Interplay between Finasteride-Induced Androgen Imbalance, Endoplasmic Reticulum Stress, Oxidative Stress, and Liver Disorders in Paternal and Filial Generation Biomedicines · 2022
    8. Connection between granulosa cell pyroptosis and oocyte endoplasmic reticulum stress in a mouse model of polycystic ovary syndrome Journal of Ovarian Research · 2025 · 2 citations
    9. A bibliometric analysis of endoplasmic reticulum stress and atherosclerosis Frontiers in Physiology · 2024 · 1 citations
    10. OBESITY-RELATED FACTORS INVOLVED IN ENDOPLASMIC RETICULUM STRESS INDUCTION IN ADIPOCYTES Durham e-Theses (Durham University) · 2015
    11. Ginkgolide B-loaded detachable microneedles attenuate androgenetic alopecia by suppressing endoplasmic reticulum stress via the Nrf2/HO-1 pathway Free Radical Biology and Medicine · 2026
    12. Corrigendum to “Ginkgolide B-loaded detachable microneedles attenuate androgenetic alopecia by suppressing endoplasmic reticulum stress via the Nrf2/ HO-1 pathway” [Free Radic. Biol. Med. 256, (2026), 1-14] Free Radical Biology and Medicine · 2026
    13. Forsythiaside A ameliorates sepsis-induced acute kidney injury via anti-inflammation and antiapoptotic effects by regulating endoplasmic reticulum stress BMC Complementary Medicine and Therapies · 2023 · 24 citations
    14. Forsythiaside A protects against focal cerebral ischemic injury by mediating the activation of the Nrf2 and endoplasmic reticulum stress pathways Molecular Medicine Reports · 2019 · 12 citations
    15. Particulate matter 2.5 damages skin cells by inducing oxidative stress, subcellular organelle dysfunction, and apoptosis Archives of Toxicology · 2018 · 215 citations
    16. 554 Repurposing a clinical antimalarial for the therapeutic induction of lethal ER stress targeting BRAF-kinase inhibitor-resistant malignant melanoma Journal of Investigative Dermatology · 2016
    17. Ichthyosis follicularis, alopecia, and photophobia (IFAP) syndrome Orphanet Journal of Rare Diseases · 2011 · 71 citations
    18. Keratins as an Inflammation Trigger Point in Epidermolysis Bullosa Simplex International Journal of Molecular Sciences · 2021 · 40 citations
    19. Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer’s disease Translational Psychiatry · 2021 · 12 citations
    20. 0961 Exploring mitochondrial dysfunction in miniaturized hair follicles: Insights into androgenetic alopecia Journal of Investigative Dermatology · 2025
    21. Acquired curved hair is caused by fusion of multiple hair matrix cells Journal of Dermatological Science · 2024
    22. Bilayer Silk Fibroin/Sodium Alginate Scaffold Delivered hUC-MSCs to Enhance Skin Scarless Healing and Hair Follicle Regeneration with the IRE1/XBP1 Pathway Inhibition ACS Biomaterials Science & Engineering · 2023
    23. AB032. Development of new treatment modality for male infertility by using phytopharmaceuticals Translational andrology and urology · 2018
    24. Protective effect of DA-9401 in finasteride-induced apoptosis in rat testis: inositol requiring kinase 1 and c-Jun N-terminal kinase pathway DOAJ (DOAJ: Directory of Open Access Journals) · 2017
    25. Clinical Snippets Journal of Investigative Dermatology · 2015
    26. A case of <i>MBTPS1</i>‐related disorder due to compound heterozygous variants in <i>MBTPS1</i> gene: Genotype–phenotype expansion and the emergence of a novel syndrome American journal of medical genetics. Part A · 2023
    27. G4, is a new transgenic mouse model for the polycystic ovaries syndrome 2019
    28. 187 Protective Effect of DA-9401 on Acute use of Finasteride on Sprague–Dawley Rats The Journal of Sexual Medicine · 2018
    29. Transcriptomic inspection revealed a possible pathway regulating the formation of the high-quality brush hair in Chinese Haimen goat ( <i>Capra hircus</i> ) Royal Society Open Science · 2018 · 11 citations
    30. Protective effect of DA-9401 in finasteride-induced apoptosis in rat testis: inositol requiring kinase 1 and c-Jun N-terminal kinase pathway Drug Design Development and Therapy · 2017 · 18 citations