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Glossary Endoplasmic Reticulum

network of membranes in cells for protein and lipid synthesis

The Endoplasmic Reticulum (ER) is a network of membranes within a cell that plays a crucial role in the synthesis, folding, modification, and transport of proteins and lipids. There are two types: Rough ER, which is studded with ribosomes and primarily involved in protein synthesis, and Smooth ER, which lacks ribosomes and is involved in lipid synthesis and detoxification processes.

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research Endoplasmic reticulum in health and disease: the 12th International Calreticulin Workshop, Delphi, Greece

13 citations , November 2017 in “Journal of Cellular and Molecular Medicine”

This workshop reviewed various roles of endoplasmic reticulum chaperones, including calreticulin, in cellular signaling, disease states, and potential markers, but reports no new experimental findings.

research Endoplasmic reticulum stress at the crossroads of progeria and atherosclerosis

11 citations , March 2019 in “EMBO molecular medicine”

This paper reviews the role of endoplasmic reticulum stress and the unfolded protein response in Hutchinson-Gilford progeria syndrome-related atherosclerosis, especially in vascular smooth muscle cells, but reports no clinical findings; intervention in these pathways is suggested as a potential therapeutic strategy.

Probiotic-Functionalized Silk Fibroin/Sodium Alginate Scaffolds With Endoplasmic Reticulum Stress-Relieving Properties For Promoted Scarless Wound Healing

research Probiotic-Functionalized Silk Fibroin/Sodium Alginate Scaffolds with Endoplasmic Reticulum Stress-Relieving Properties for Promoted Scarless Wound Healing

7 citations , January 2023 in “ACS Applied Materials & Interfaces”

This study found that probiotic-functionalized silk fibroin/alginate scaffolds, loaded with Lactobacillus casei, promoted scarless wound healing and hair follicle regeneration in infected wounds in rats.

research A novel MBTPS2 variant associated with BRESHECK syndrome impairs sterol‐regulated transcription and the endoplasmic reticulum stress response

5 citations , October 2021 in “American Journal of Medical Genetics Part A”

This case report identifies a novel maternally inherited MBTPS2 variant associated with an expanded phenotypic spectrum of BRESHECK syndrome, including cytopenias, bone marrow fibrosis, and chronic diarrhea.

Melatonin Protects Cochlear Hair Cells from Nicotine-Induced Injury Through Inhibiting Apoptosis, Inflammation, Oxidative Stress, and Endoplasmic Reticulum Stress

research Melatonin protects cochlear hair cells from nicotine‐induced injury through inhibiting apoptosis, inflammation, oxidative stress and endoplasmic reticulum stress

5 citations , July 2021 in “Basic & Clinical Pharmacology & Toxicology”

This study found that nicotine caused damage to cochlear hair cells in vitro, and melatonin might protect against this damage, indicating its potential as a treatment for smoking-induced hearing loss.

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community Don't use PP405 from everychem. it is likely fake.

63 upvotes 1 year ago

PP405 from Everychem is likely fake and potentially harmful, with concerns about its stability and the risk of using the wrong MPC inhibitor, which could damage hair follicles. The real PP405 was studied under strict conditions, and DIY attempts are discouraged due to unknown formulation and quality control.

community Minoxidil inhibits lysyl hydroxylase which is needed to produce collagen. If I take 2,5...5 mg of minoxidil every day can I cause my skin to age prematurely?

32 upvotes 1 year ago

Oral minoxidil is effective for hair loss and unlikely to significantly affect collagen synthesis, making it a safe option without causing premature skin aging. Users report positive hair regrowth without noticeable skin aging.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community PP405 vs Hair Cloning – Which Would Be Better for NW7 to NW1?

in Research/Science 20 upvotes 1 year ago

PP405 and hair cloning are discussed as potential treatments for reversing hair loss from Norwood 7 to Norwood 1. Hair cloning is seen as a more permanent solution, while PP405's effectiveness and long-term effects remain uncertain.

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