Hesperidin from Orange Peel as a Promising Skincare Bioactive: An Overview

The review highlights hesperidin, a flavonoid from orange peels, as a promising bioactive for skincare due to its antioxidant, anti-inflammatory, and anticarcinogenic properties. It shows potential in addressing skin aging, UV damage, hyperpigmentation, wound healing, and skin cancer. Sustainable extraction methods align with circular economy principles. Despite challenges like poor water solubility and low skin absorption, new formulation technologies are being developed. Hesperidin's efficacy is supported by numerous studies, making it a versatile and valuable component in cosmetic and therapeutic skincare products. Further research is needed to fully understand its molecular mechanisms and optimize its use.