4 citations
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October 2020 in “Toxicology Mechanisms and Methods” Hesperidin protects rat testicles from finasteride damage and improves sperm health.
3 citations
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February 2024 in “International journal of molecular sciences” Hesperidin from orange peels is a promising natural ingredient for skincare due to its multiple beneficial properties.
January 2024 in “Reproductive toxicology” Hesperidin helps protect against testicular damage caused by finasteride.
9 citations
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March 2016 in “Natural Product Research” Some flavonoids may help with hair growth by affecting blood vessel function in hair follicles.
December 2025 in “Chemical Biology & Drug Design” This study investigates the potential of nitric oxide (NO) donors in treating alopecia by examining their physiological mechanisms. Researchers screened chemical targets of seven NO donors and identified differentially expressed genes (DEGs) for three types of alopecia: androgenic alopecia (AGA), alopecia areata (AA), and central centrifugal cicatricial alopecia (CCCA). They found 339 chemical targets and identified 237, 266, and 1158 DEGs for AGA, AA, and CCCA, respectively. The study focused on 20 CCCA-related targets and discovered that hesperidin (HP) may regulate apoptosis and senescence pathways in hair follicle cells, potentially mitigating hair loss. This research highlights the molecular mechanisms of NO donors in hair follicle protection, suggesting future NO-based interventions for clinical applications.