Screening Potential Drugs From Nitric Oxide Donors for Treating Alopecia Based on Network Pharmacology and Experimental Validation

    December 2025 in “ Chemical Biology & Drug Design ”
    Pan Guo, Mengke Sun, Hong Cui … Lizhi Hu
    Studysummary This study suggests that hesperidin may regulate pathways in hair follicle cells to help mitigate hair loss, revealing molecular mechanisms of nitric oxide donor-mediated hair follicle protection.
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    Research cited in this study 11

    1. Nitric Oxide Synergizes Minoxidil Delivered by Transdermal Hyaluronic Acid Liposomes for Multimodal Androgenetic Alopecia Therapy Bioactive Materials · 2023
    2. Nitric Oxide: Physiological Functions, Delivery, and Biomedical Applications Advanced Science · 2023
    3. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    4. Alopecia and Associated Toxic Agents: A Systematic Review Skin appendage disorders · 2018
    5. Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men – Short Version Journal of The European Academy of Dermatology and Venereology · 2017
    6. Oxidative Stress Management in the Hair Follicle: Could Targeting NRF2 Counter Age-Related Hair Disorders and Beyond? BioEssays · 2017
    7. The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2017
    8. Central Centrifugal Cicatricial Alopecia: Challenges and Solutions Clinical, Cosmetic and Investigational Dermatology · 2016
    9. Effects of Flavonoid Derivatives on Human Microvascular Endothelial Cells Natural Product Research · 2016
    10. Androgenetic Alopecia: Clinical Features, Classification, and Treatments Endocrinology and Metabolism Clinics of North America · 2007
    11. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001