Multistage Transdermal Nitric Oxide Delivery System for the Efficient Treatment of Androgenic Alopecia

November 2024 in “ ACS Materials Letters ”

Hui Xing, Xinlin Jiang, Ziyi Zhao, Yuhui Yang, Zhen Wang, Jing Wang, Guodong Sun, Shixin Liu, Dong Ma

nitric oxide transdermal delivery system androgenic alopecia poly(vinyl alcohol) film hyaluronic acid liposomes PVA@HL/NONOate minoxidil angiogenesis hair follicles HIF-1 signaling pathway inflammation NO PVA film HA liposomes AGA

TLDR The new nitric oxide delivery system may effectively treat hair loss by improving hair follicle health and reducing inflammation.

The study presents a novel multistage transdermal nitric oxide (NO) delivery system using a poly(vinyl alcohol) film loaded with hyaluronic acid liposomes (PVA@HL/NONOate) for treating androgenic alopecia (AGA). This system aims to overcome the limitations of minoxidil by enhancing NO bioavailability, which promotes angiogenesis and improves nutrient supply to hair follicles. The HA liposomes ensure efficient NO loading and extended release, while the PVA film enhances skin penetration. Low-concentration NO was found to enhance hair follicle vitality, repair blood vessels, and reduce inflammation by modulating the HIF-1 signaling pathway and downregulating inflammatory gene expressions. This approach offers a promising alternative for AGA treatment by effectively targeting hair follicle health and reducing inflammation.

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