1 citations,
July 2023 in “International Journal of Molecular Sciences” Treating fat stem cells with low oxygen boosts hair growth cell growth through specific signaling pathways.
November 2024 in “Research Square (Research Square)” This study investigates the role of lipids in hair growth, particularly through the HIF-1 signaling pathway. Researchers observed reduced lipid metabolism in the scalp tissues of patients with androgenetic alopecia. Supplementing lipids in culture mediums enhanced hair growth-related gene expression and the proliferation of human dermal papilla cells (DPCs). RNA-sequencing and HIF-1a knockdown experiments identified HIF-1a as a key regulator in lipid-induced upregulation of trichogenic genes. Additionally, lipids were shown to promote the elongation of hair-shaft-like structures in vitro. These findings suggest that targeting lipid metabolism and HIF-1 signaling could be a promising approach for treating hair loss.
1 citations,
July 2022 in “British Journal of Dermatology” Targeting specific genes in certain pathways may help treat male pattern baldness.
10 citations,
November 2022 in “Protein & Cell” Quercetin significantly helps hair growth by activating hair follicles and improving blood vessel formation around them.
1 citations,
January 2023 in “Science Advances” The skin's microbiome helps hair regrow by boosting certain cell signals and metabolism.