Microneedle Mediated Transdermal Delivery of Beta-Sitosterol Loaded Nanostructured Lipid Nanoparticles for Androgenic Alopecia

September 2022 in “ Drug Delivery ”

Kousalya Prabahar, Ubaidulla Udhumansha, Nehal M. Elsherbiny, Mona Qushawy

β-sitosterol nanostructured lipid carriers polymeric microneedles androgenic alopecia testosterone anagen/telogen ratio beta-sitosterol NLC MN

TLDR The microneedle system effectively promotes hair growth for treating androgenic alopecia.

This study investigates a transdermal delivery system for β-sitosterol (BS) using nanostructured lipid carriers (NLC) incorporated into polymeric microneedles (MN) to treat androgenic alopecia. The optimized BS-loaded NLCs were tested on testosterone-induced alopecia rats, showing a significantly higher skin penetration and steady-state flux compared to NLC alone. The anagen/telogen ratio improved significantly with NLC and NLC-MN treatments, indicating enhanced hair growth, with the NLC-MN system showing the most significant results. The findings suggest that the NLC-MN transdermal system could be an effective treatment for androgenic alopecia.

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Research cited in this study

11 / 11 results

research Latanoprost Loaded in Polymeric Nanocapsules for Effective Topical Treatment of Alopecia

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Identification of a New Plant Extract for Androgenic Alopecia Treatment Using a Non-Radioactive Human Hair Dermal Papilla Cell-Based Assay

research Identification of a New Plant Extract for Androgenic Alopecia Treatment Using a Non-Radioactive Human Hair Dermal Papilla Cell-Based Assay

17 citations , December 2015 in “BMC Complementary and Alternative Medicine”

A new plant extract from Avicennia marina could potentially be used to treat common hair loss.

research Follicular Delivery of Spironolactone via Nanostructured Lipid Carriers for Management of Alopecia

89 citations , November 2014 in “International Journal of Nanomedicine”

Using nanostructured lipid carriers to deliver spironolactone could improve treatment for hair loss.

research Effect of Adiantum Capillus-Veneris Linn on an Animal Model of Testosterone-Induced Hair Loss

13 citations , January 2014 in “PubMed”

Adiantum capillus-veneris Linn reduced hair loss and improved hair growth in mice with testosterone-induced alopecia.

research Development and Characterization of Phyto-Vesicles of Beta-Sitosterol for the Treatment of Androgenetic Alopecia

14 citations , December 2011 in “Archives of Dermatological Research”

Phyto-vesicles of β-sitosterol may effectively treat hair loss.

research Effect of Citrullus Colocynthis Schrad Fruits on Testosterone-Induced Alopecia

31 citations , September 2009 in “Natural Product Research”

Citrullus colocynthis fruit extract may effectively treat testosterone-related hair loss, similar to finasteride.

A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-Alpha-Reductase in the Treatment of Androgenetic Alopecia

research A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-Alpha-Reductase in the Treatment of Androgenetic Alopecia

65 citations , April 2002 in “Journal of Alternative and Complementary Medicine”

Plant extracts effectively reduce hair loss and increase growth, offering a safe alternative treatment.

research A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-Alpha-Reductase in the Treatment of Androgenetic Alopecia

68 citations , April 2002 in “Journal of Alternative and Complementary Medicine”

Natural 5AR inhibitors effectively improve mild to moderate hair loss in men.

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